Macrophages play an important role in tissue homeostasis, tissue remodeling, immune
response, and progression of cancer. Consequently, macrophages exhibit significant …

This review summarizes the role of macrophages in adipose tissue remodeling, particularly
focusing on the paracrine loop between adipocytes and macrophages. The adipose tissue …

Objective—Weight gain is associated with infiltration of fat by macrophages, suggesting that
they are an important source of inflammation in obese adipose tissue. Here we developed …

Although there are numerous experimental data indicating that oxidative stress plays a role
in the initiation and progression of alcohol-induced liver disease (ALD), this work has yet to …

Inflammatory mediators activate the transcriptional complex HIF-1 (hypoxia-inducible factor-
1), the key regulator of hypoxia-induced gene expression. Here we report that bacterial LPS …

Acute respiratory distress syndrome (ARDS) is characterized by an excessive acute
inflammatory response in lung parenchyma, which ultimately leads to refractory hypoxemia …

To better understand the molecular basis of chronic obstructive pulmonary disease (COPD),
we used serial analysis of gene expression (SAGE) and microarray analysis to compare the …

The ototoxicity of cisplatin, a widely used chemotherapeutic agent, involves a number of
mechanisms, including perturbation of redox status, increase in lipid peroxidation, and …

LPS stimulation of monocytes/macrophages induces the expression of genes encoding
proinflammatory cytokines and the procoagulant protein, tissue factor. Induction of these …

Early growth response 1 (EGR1) is a multifunctional mammalian transcription factor capable
of both enhancing and/or inhibiting gene expression. EGR1 can be activated by a wide array …