The role of androgens and estrogens on healthy aging and longevity

AM Horstman, EL Dillon, RJ Urban… - … Series A: Biomedical …, 2012 - academic.oup.com
Aging is associated with a loss of sex hormone in both men (andropause) and women
(menopause). In men, reductions in testosterone can trigger declines in muscle mass, bone …

Nutrition and longevity–From mechanisms to uncertainties

C Ekmekcioglu - Critical reviews in food science and nutrition, 2020 - Taylor & Francis
Genetic, environmental, and lifestyle factors primarily determine the lifespan of humans.
From these, nutrition is a key component affecting our health, and several studies …

Relationships of low serum vitamin D3with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity

AT McGill, JM Stewart, FE Lithander, CM Strik… - Nutrition journal, 2008 - Springer
Low serum 25 hydroxyvitamin D 3 (vitamin D 3) is known to perturb cellular function in many
tissues, including the endocrine pancreas, which are involved in obesity and type II diabetes …

Caloric restriction: from soup to nuts

SR Spindler - Ageing research reviews, 2010 - Elsevier
Caloric restriction (CR), reduced protein, methionine, or tryptophan diets; and reduced
insulin and/or IGFI intracellular signaling can extend mean and/or maximum lifespan and …

Nutrients and pathways that regulate health span and life span

C Pignatti, S D'Adamo, C Stefanelli, F Flamigni… - Geriatrics, 2020 - mdpi.com
Both life span and health span are influenced by genetic, environmental and lifestyle factors.
With the genetic influence on human life span estimated to be about 20–25%, epigenetic …

[HTML][HTML] Role of zinc and copper in erythropoiesis in patients on hemodialysis

A Takahashi - Journal of Renal Nutrition, 2022 - Elsevier
Plasma zinc concentrations are decreased in patients on hemodialysis; zinc
supplementation increases hemoglobin levels and reduces erythropoietin-stimulating agent …

Effect of protein intake on bone and muscle mass in the elderly

P de Souza Genaro, LA Martini - Nutrition reviews, 2010 - academic.oup.com
The aging process is frequently characterized by an involuntary loss of muscle (sarcopenia)
and bone (osteoporosis) mass. Both chronic diseases are associated with decreased …

Calcium, vitamin D supplementation, and physical function in the Women's Health Initiative

RL Brunner, B Cochrane, RD Jackson, J Larson… - Journal of the American …, 2008 - Elsevier
OBJECTIVES: The Women's Health Initiative (WHI) randomized trial of calcium/vitamin D
supplementation found reduced bone loss with active treatment compared to placebo and …

Cell apoptosis induced by zinc deficiency in osteoblastic MC3T3-E1 cells via a mitochondrial-mediated pathway

B Guo, M Yang, D Liang, L Yang, J Cao… - Molecular and cellular …, 2012 - Springer
Deficiency of zinc plays an important role in the pathogenesis of osteoporosis; however, the
underlying mechanism is not well understood. Apoptosis of osteoblast causing the loss of …

Associations of whole blood zinc levels with coronary artery calcification and future cardiovascular events in CKD patients

D Zhang, Y Zhu, H Li, Y Wang, Z Niu, W Zhou… - … Trace Element Research, 2024 - Springer
This study was conducted to compare the differences of the whole blood zinc concentration
in patients with chronic kidney disease (CKD) as compared to healthy controls, and to …