Lipid–drug conjugates (LDCs) are drug molecules that have been covalently modified with
lipids. The conjugation of lipids to drug molecules increases lipophilicity and also changes …

Epithelial–mesenchymal transition (EMT) is an important process for cancer metastasis,
drug resistance, and cancer stem cells. Activation of fibroblast growth factor receptor 1 …

Nanocarriers have the capability to deliver a variety of drugs to disease sites. Different
biological barriers prevent the successful delivery of nanoformulations to target sites …

Nanoparticle (NP) drug loading is one of the key defining characteristics of an NP
formulation. However, the effect of NP drug loading on therapeutic efficacy and …

PLGA nanotherapeutics though representing a most promising platform for targeted cancer
therapy are confronted with low stability and insufficient tumor cell uptake. Here, we report …

Long-circulating nanoparticles are essential for increasing tumor accumulation to provide
therapeutic efficacy. While it is known that tumor presence can alter the immune system, very …

Lung cancer is the leading cancer and has the highest death rate. The epidermal growth
factor receptor (EGFR) tyrosine kinase inhibitor (TKI) erlotinib has had a promising response …

Cisplatin is a cytotoxic drug used as a first-line therapy for a wide variety of cancers.
However, significant renal and neurological toxicities limit its clinical use. It has been …

The pathologies and lethality of lung cancers are associated with smoking, lifestyle, and
genomic factors. Several experimental mouse models of lung cancer, including those …

Purpose Lung adenocarcinoma is characterized by a poor prognosis and high mortality
worldwide. In this study, we purposed to use the live imaging techniques and a reporter …