Hidradenitis suppurativa: an update on epidemiology, phenotypes, diagnosis, pathogenesis, comorbidities and quality of life
TV Nguyen, G Damiani, LAV Orenstein… - Journal of the …, 2021 - Wiley Online Library
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that severely impairs
patients' quality of life. It is characterized by recurrent painful nodules, abscesses and …
patients' quality of life. It is characterized by recurrent painful nodules, abscesses and …
The Genetics of Hidradenitis Suppurativa.
JR Ingram - Dermatologic clinics, 2016 - europepmc.org
A family history of hidradenitis suppurativa (HS) is reported by about one-third of patients,
and the pattern of inheritance suggests a single gene disorder inherited as an autosomal …
and the pattern of inheritance suggests a single gene disorder inherited as an autosomal …
Insights into hidradenitis suppurativa
KR van Straalen, EP Prens, JE Gudjonsson - Journal of Allergy and Clinical …, 2022 - Elsevier
Hidradenitis suppurativa (HS) is a chronic, debilitating, inflammatory skin disorder with a
prevalence of around 1% and a profound impact on patients' quality of life. Characteristic …
prevalence of around 1% and a profound impact on patients' quality of life. Characteristic …
New precision medicine avenues to the prevention of Alzheimer's disease from insights into the structure and function of γ-secretases
B De Strooper, E Karran - The EMBO Journal, 2024 - embopress.org
Two phase-III clinical trials with anti-amyloid peptide antibodies have met their primary goal,
ie slowing of Alzheimer's disease (AD) progression. However, antibody therapy may not be …
ie slowing of Alzheimer's disease (AD) progression. However, antibody therapy may not be …
Mechanisms of neurodegeneration—Insights from familial Alzheimer's disease
L Chávez-Gutiérrez, M Szaruga - Seminars in Cell & Developmental …, 2020 - Elsevier
The rising prevalence of Alzheimer's disease (AD), together with the lack of effective
treatments, portray it as one of the major health challenges of our times. Untangling AD …
treatments, portray it as one of the major health challenges of our times. Untangling AD …
[PDF][PDF] Low prevalence of GSC gene mutations in a large cohort of predominantly caucasian patients with hidradenitis suppurativa
S Duchatelet, S Miskinyte, M Delage… - Journal of Investigative …, 2020 - Elsevier
Hidradenitis suppurativa (HS) is a chronic dermatosis characterized by nodules and
abscesses in apocrine gland-bearing sites. Mutations in three gamma-secretase complex …
abscesses in apocrine gland-bearing sites. Mutations in three gamma-secretase complex …
A systematic review and critical evaluation of reported pathogenic sequence variants in hidradenitis suppurativa
JW Frew, DA Vekic, J Woods… - British Journal of …, 2017 - academic.oup.com
Hidradenitis suppurativa (HS) is a severe chronic inflammatory disorder characterized by
recurrent painful deep‐seated nodules with a predilection to the apocrine‐bearing areas of …
recurrent painful deep‐seated nodules with a predilection to the apocrine‐bearing areas of …
[HTML][HTML] Presenilins and γ-secretase in membrane proteostasis
N Oikawa, J Walter - Cells, 2019 - mdpi.com
The presenilin (PS) proteins exert a crucial role in the pathogenesis of Alzheimer disease
(AD) by mediating the intramembranous cleavage of amyloid precursor protein (APP) and …
(AD) by mediating the intramembranous cleavage of amyloid precursor protein (APP) and …
Nicastrin mutations in familial acne inversa impact keratinocyte proliferation and differentiation through the Notch and phosphoinositide 3‐kinase/AKT signalling …
X Xiao, Y He, C Li, X Zhang, H Xu… - British Journal of …, 2016 - academic.oup.com
Background Acne inversa (AI) is a chronic inflammatory skin disease with an autosomal
dominant inheritance pattern. Mutations of the gene encoding nicastrin (NCSTN), a cofactor …
dominant inheritance pattern. Mutations of the gene encoding nicastrin (NCSTN), a cofactor …
Acne and hidradenitis suppurativa
A Pink, F Anzengruber… - British Journal of …, 2018 - academic.oup.com
Acne and hidradenitis suppurativa (HS) both centre on hair follicles. They often occur
together as part of the acne tetrad, but are found in distinct localizations. Acne is primarily …
together as part of the acne tetrad, but are found in distinct localizations. Acne is primarily …