TRPC channels: Structure, function, regulation and recent advances in small molecular probes
Transient receptor potential canonical (TRPC) channels constitute a group of receptor-
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …
Structure–functional intimacies of transient receptor potential channels
Although a unifying characteristic common to all transient receptor potential (TRP) channel
functions remains elusive, they could be described as tetramers formed by subunits with six …
functions remains elusive, they could be described as tetramers formed by subunits with six …
Structure of the receptor-activated human TRPC6 and TRPC3 ion channels
Q Tang, W Guo, L Zheng, JX Wu, M Liu, X Zhou… - Cell research, 2018 - nature.com
TRPC6 and TRPC3 are receptor-activated nonselective cation channels that belong to the
family of canonical transient receptor potential (TRPC) channels. They are activated by …
family of canonical transient receptor potential (TRPC) channels. They are activated by …
Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy
Chronic neurohormonal and mechanical stresses are central features of heart disease.
Increasing evidence supports a role for the transient receptor potential canonical channels …
Increasing evidence supports a role for the transient receptor potential canonical channels …
TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology
Loss or dysfunction of podocytes is a major cause of glomerular kidney disease. Several
genetic forms of glomerular disease are caused by mutations in genes that encode structural …
genetic forms of glomerular disease are caused by mutations in genes that encode structural …
[HTML][HTML] Mechanosensitive ion channels in cell migration
BC Coutino, R Mayor - Cells & Development, 2021 - Elsevier
Cellular processes are initiated and regulated by different stimuli, including mechanical
forces. Cell membrane mechanosensors represent the first step towards the conversion of …
forces. Cell membrane mechanosensors represent the first step towards the conversion of …
Trpc6 inactivation confers protection in a model of severe nephrosis in rats
Mutations in canonical transient receptor potential-6 (TRPC6) channels give rise to rare
familial forms of focal and segmental glomerulosclerosis (FSGS). Here we examined a …
familial forms of focal and segmental glomerulosclerosis (FSGS). Here we examined a …
Heteromerization of TRP channel subunits: extending functional diversity
W Cheng, C Sun, J Zheng - Protein & cell, 2010 - Springer
Transient receptor potential (TRP) channels are widely found throughout the animal
kingdom. By serving as cellular sensors for a wide spectrum of physical and chemical …
kingdom. By serving as cellular sensors for a wide spectrum of physical and chemical …
Exploration of selected monoterpenes as potential TRPC channel family modulator in lung cancer, an in-silico upshot
Lung cancer is still the most frequent cause of cancer-related death, accounting for nearly
two million cases yearly. As cancer is a multifactorial disease, developing novel molecular …
two million cases yearly. As cancer is a multifactorial disease, developing novel molecular …
Role of Store-Operated Ca2+ Entry in the Pulmonary Vascular Remodeling Occurring in Pulmonary Arterial Hypertension
B Masson, D Montani, M Humbert, V Capuano… - Biomolecules, 2021 - mdpi.com
Pulmonary arterial hypertension (PAH) is a severe and multifactorial disease. PAH
pathogenesis mostly involves pulmonary arterial endothelial and pulmonary arterial smooth …
pathogenesis mostly involves pulmonary arterial endothelial and pulmonary arterial smooth …