The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …

Potassium channels ubiquitously exist in nearly all kingdoms of life and perform diverse but
important functions. Since the first atomic structure of a prokaryotic potassium channel …

The growing interest for comparing protein internal dynamics owes much to the realisation
that protein function can be accompanied or assisted by structural fluctuations and …

Biological ion channels are nanoscale transmembrane pores. When water and ions are
enclosed within the narrow confines of a sub-nanometer hydrophobic pore, they exhibit …

We present the first structure of the human Kir2. 1 channel containing both transmembrane
domain (TMD) and cytoplasmic domain (CTD). Kir2. 1 channels are strongly inward …

Mechanical and thermal activation of ion channels is central to touch, thermosensation, and
pain. The TRAAK/TREK K 2P potassium channel subfamily produces background currents …

Pharmacological activation of voltage-gated ion channels by ligands serves as the basis for
therapy and mainly involves a classic gating mechanism that augments the native voltage …

Total chemical synthesis provides a unique approach for the access to uncontaminated,
monodisperse, and more importantly, post-translationally modified membrane proteins. In …

Over the last decade, we have seen an enormous increase in the number of experimental
studies on two-pore-domain potassium channels (K 2P-channels). The collection of reviews …

K+ channels fulfill roles spanning from the control of excitability to the regulation of
transepithelial transport. Here we review two groups of K+ channels, pH-regulated K2P …