Covering: 2005 up to 2019 Natural products are of paramount importance in human
medicine. Not only are most antibacterial and anticancer drugs derived directly from or …

Covering: 1999 to 2014 Type 1, α/β hydrolase-like thioesterase (TE) domains are essential
offloading enzymes, releasing covalently bound products from fatty acid, polyketide, and non …

A synthetic biology method based on heterologous biosynthesis coupled with genome
mining is a promising approach for increasing the opportunities to rationally access natural …

Secondary (specialized) metabolites, produced by bacteria, fungi, plants, and other
organisms, exhibit enormous structural variation, and consequently display a wide range of …

Fungi are a prolific source of bioactive compounds, some of which have been developed as
essential medicines and life-enhancing drugs. Genome sequencing has revealed that fungi …

Filamentous fungi produce a very wide range of complex and often bioactive metabolites,
demonstrating their inherent ability as hosts of complex biosynthetic pathways. Recent …

Synthetic biologists construct biological components and systems to look into biological
phenomena and drive a myriad of practical applications that aim to tackle current global …

As a robust, fast growing and genetically tractable organism, the budding yeast
Saccharomyces cerevisiae is one of the most widely used hosts in biotechnology. Its …

Orsellinic acid (OA) derivatives are produced by filamentous fungi using nonreducing
polyketide synthases (nrPKSs). The chain‐releasing thioesterase (TE) domains of such …

Synthetic biology (SB) is an emerging discipline, which is slowly reorienting the field of drug
discovery. For thousands of years, living organisms such as plants were the major source of …