Mechanical properties of lipid bilayers from molecular dynamics simulation

RM Venable, FLH Brown, RW Pastor - Chemistry and physics of lipids, 2015 - Elsevier
Lipid areas (A ℓ), bilayer area compressibilities (KA), bilayer bending constants (KC), and
monolayer spontaneous curvatures (c 0) from simulations using the CHARMM36 force field …

Biological membrane organization and cellular signaling

X Cheng, JC Smith - Chemical reviews, 2019 - ACS Publications
To execute their many vital functions, cell membranes are highly organized. Here, we review
how membrane structure shapes signal transduction across membranes. Recent …

Nonuniversal impact of cholesterol on membranes mobility, curvature sensing and elasticity

M Pöhnl, MFW Trollmann, RA Böckmann - Nature Communications, 2023 - nature.com
Biological membranes, composed mainly of phospholipids and cholesterol, play a vital role
as cellular barriers. They undergo localized reshaping in response to environmental cues …

Cholesterol stiffening of lipid membranes

FT Doole, T Kumarage, R Ashkar, MF Brown - The Journal of Membrane …, 2022 - Springer
Biomembrane order, dynamics, and other essential physicochemical parameters are
controlled by cholesterol, a major component of mammalian cell membranes. Although …

Monolayer spontaneous curvature of raft-forming membrane lipids

B Kollmitzer, P Heftberger, M Rappolt, G Pabst - Soft matter, 2013 - pubs.rsc.org
Monolayer spontaneous curvatures for cholesterol, DOPE, POPE, DOPC, DPPC, DSPC,
POPC, SOPC, and egg sphingomyelin were obtained using small-angle X-ray scattering …

Determination of bending rigidity and tilt modulus of lipid membranes from real-space fluctuation analysis of molecular dynamics simulations

M Doktorova, D Harries, G Khelashvili - Physical Chemistry Chemical …, 2017 - pubs.rsc.org
We have recently developed a novel computational methodology (termed RSF for Real-
Space Fluctuations) to quantify the bending rigidity and tilt modulus of lipid membranes from …

Effect of DMSO on the mechanical and structural properties of model and biological membranes

B Gironi, Z Kahveci, B McGill, BD Lechner, S Pagliara… - Biophysical journal, 2020 - cell.com
Dimethyl sulfoxide (DMSO) is widely used in a number of biological and biotechnological
applications, mainly because of its effects on the cell plasma membrane, but the molecular …

Mechanical properties of nanoscopic lipid domains

JD Nickels, X Cheng, B Mostofian… - Journal of the …, 2015 - ACS Publications
The lipid raft hypothesis presents insights into how the cell membrane organizes proteins
and lipids to accomplish its many vital functions. Yet basic questions remain about the …

Capturing phase behavior of ternary lipid mixtures with a refined martini coarse-grained force field

TS Carpenter, CA López, C Neale… - Journal of chemical …, 2018 - ACS Publications
Whether lipid rafts are present in the membranes of living cells remains hotly disputed
despite their incontrovertible existence in liposomes at 298 K. In attempts to resolve this …

Determination of biomembrane bending moduli in fully atomistic simulations

ZA Levine, RM Venable, MC Watson… - Journal of the …, 2014 - ACS Publications
The bilayer bending modulus (K c) is one of the most important physical constants
characterizing lipid membranes, but precisely measuring it is a challenge, both …