Mechanical properties of lipid bilayers from molecular dynamics simulation
Lipid areas (A ℓ), bilayer area compressibilities (KA), bilayer bending constants (KC), and
monolayer spontaneous curvatures (c 0) from simulations using the CHARMM36 force field …
monolayer spontaneous curvatures (c 0) from simulations using the CHARMM36 force field …
Biological membrane organization and cellular signaling
To execute their many vital functions, cell membranes are highly organized. Here, we review
how membrane structure shapes signal transduction across membranes. Recent …
how membrane structure shapes signal transduction across membranes. Recent …
Nonuniversal impact of cholesterol on membranes mobility, curvature sensing and elasticity
M Pöhnl, MFW Trollmann, RA Böckmann - Nature Communications, 2023 - nature.com
Biological membranes, composed mainly of phospholipids and cholesterol, play a vital role
as cellular barriers. They undergo localized reshaping in response to environmental cues …
as cellular barriers. They undergo localized reshaping in response to environmental cues …
Cholesterol stiffening of lipid membranes
Biomembrane order, dynamics, and other essential physicochemical parameters are
controlled by cholesterol, a major component of mammalian cell membranes. Although …
controlled by cholesterol, a major component of mammalian cell membranes. Although …
Monolayer spontaneous curvature of raft-forming membrane lipids
Monolayer spontaneous curvatures for cholesterol, DOPE, POPE, DOPC, DPPC, DSPC,
POPC, SOPC, and egg sphingomyelin were obtained using small-angle X-ray scattering …
POPC, SOPC, and egg sphingomyelin were obtained using small-angle X-ray scattering …
Determination of bending rigidity and tilt modulus of lipid membranes from real-space fluctuation analysis of molecular dynamics simulations
M Doktorova, D Harries, G Khelashvili - Physical Chemistry Chemical …, 2017 - pubs.rsc.org
We have recently developed a novel computational methodology (termed RSF for Real-
Space Fluctuations) to quantify the bending rigidity and tilt modulus of lipid membranes from …
Space Fluctuations) to quantify the bending rigidity and tilt modulus of lipid membranes from …
Effect of DMSO on the mechanical and structural properties of model and biological membranes
B Gironi, Z Kahveci, B McGill, BD Lechner, S Pagliara… - Biophysical journal, 2020 - cell.com
Dimethyl sulfoxide (DMSO) is widely used in a number of biological and biotechnological
applications, mainly because of its effects on the cell plasma membrane, but the molecular …
applications, mainly because of its effects on the cell plasma membrane, but the molecular …
Mechanical properties of nanoscopic lipid domains
The lipid raft hypothesis presents insights into how the cell membrane organizes proteins
and lipids to accomplish its many vital functions. Yet basic questions remain about the …
and lipids to accomplish its many vital functions. Yet basic questions remain about the …
Capturing phase behavior of ternary lipid mixtures with a refined martini coarse-grained force field
Whether lipid rafts are present in the membranes of living cells remains hotly disputed
despite their incontrovertible existence in liposomes at 298 K. In attempts to resolve this …
despite their incontrovertible existence in liposomes at 298 K. In attempts to resolve this …
Determination of biomembrane bending moduli in fully atomistic simulations
ZA Levine, RM Venable, MC Watson… - Journal of the …, 2014 - ACS Publications
The bilayer bending modulus (K c) is one of the most important physical constants
characterizing lipid membranes, but precisely measuring it is a challenge, both …
characterizing lipid membranes, but precisely measuring it is a challenge, both …