A review of our current knowledge of B cell antigen uptake mechanisms, the relevance of
these processes to pathology, and outstanding questions in the field. Specific antigens …

Interactions among immune cells are essential for the development of adaptive immune
responses. The immunological synapse (IS) provides a specialized platform for integration …

The proteasome is responsible for selective degradation of most cellular proteins.
Abundantly present in the cell, proteasomes not only diffuse in the cytoplasm and the …

The recent advances in high throughput sequencing technology have drastically changed
the practice of medical diagnosis, allowing for rapid identification of hundreds of genes …

The endolysosomal system specializes in degrading cellular components and is crucial to
maintaining homeostasis and adapting rapidly to metabolic and environmental cues. Cells …

Introduction Engagement of the B-cell receptor with immobilized antigens triggers the
formation of an immune synapse (IS), a complex cellular platform where B-cells recruit …

T cell asymmetry upon specific cell–cell interactions during mammalian immunological
synapse (IS) contacts requires mammalian target of rapamycin complex (mTORC) activation …

The Caenorhabditis elegans Wnt/β-catenin asymmetry (WβA) pathway utilizes asymmetric
regulation of SYS-1/β-catenin and POP-1/TCF coactivators. WβA differentially regulates …

The loss of proteostasis due to reduced efficiency of protein degradation pathways plays a
key role in multiple age-related diseases and is a hallmark of the aging process …

B lymphocytes are pivotal components of the adaptive immune system, responsible for
producing and secreting specific antibodies against pathogens and antigens. Their …