Post-translational modification of histones provides an important regulatory platform for
processes such as gene expression, DNA replication and repair, chromosome condensation …

Histone variants are key players in shaping chromatin structure, and, thus, in regulating
fundamental cellular processes such as chromosome segregation and gene expression …

Cellular senescence is a stable proliferation arrest that suppresses tumorigenesis. Cellular
senescence and associated tumor suppression depend on control of chromatin. Histone …

Abstract Background 22q11. 2 deletion syndrome (22q11DS), a copy number variation
(CNV) disorder, occurs in approximately 1: 4000 live births due to a heterozygous …

The HIRA chaperone complex, comprised of HIRA, UBN1, and CABIN1, collaborates with
histone-binding protein ASF1a to incorporate histone variant H3. 3 into chromatin in a DNA …

The mammalian HIRA/UBN1/ASF1a complex is a histone chaperone complex that is
conserved from yeast (Saccharomyces cerevisiae) to humans. This complex preferentially …

The HIRA histone chaperone complex deposits histone H3. 3 into nucleosomes in a DNA
replication-and sequence-independent manner. As herpesvirus genomes enter the nucleus …

Endothelial cell (EC), consisting of the innermost cellular layer of all types of vessels, is not
only a barrier composer but also performing multiple functions in physiological processes. It …

Early mammalian development is crucially dependent on the establishment of oxidative
energy metabolism within the trophectoderm (TE) lineage. Unlike the inner cell mass, TE …

Skeletal muscle regeneration is an efficient stem cell-based repair system that ensures
healthy musculature. For this repair system to function continuously throughout life, muscle …