Advances on the merger of electrochemistry and transition metal catalysis for organic synthesis
Synthetic organic electrosynthesis has grown in the past few decades by achieving many
valuable transformations for synthetic chemists. Although electrocatalysis has been popular …
valuable transformations for synthetic chemists. Although electrocatalysis has been popular …
The role of the phosphorus atom in drug design
JB Rodriguez, C Gallo‐Rodriguez - ChemMedChem, 2019 - Wiley Online Library
Although the phosphorus atom is found in a variety of oxidation states, most of the
phosphorus‐containing molecules of pharmacological importance possess phosphorus in …
phosphorus‐containing molecules of pharmacological importance possess phosphorus in …
Scalable Rhodium (III)‐Catalyzed Aryl C− H Phosphorylation Enabled by Anodic Oxidation Induced Reductive Elimination
ZJ Wu, F Su, W Lin, J Song, TB Wen… - Angewandte …, 2019 - Wiley Online Library
Transition metal catalyzed C− H phosphorylation remains an unsolved challenge. Reported
methods are generally limited in scope and require stoichiometric silver salts as oxidants …
methods are generally limited in scope and require stoichiometric silver salts as oxidants …
Chiral Organophosphorus Pharmaceuticals: Properties and Application
AO Kolodiazhna, OI Kolodiazhnyi - Symmetry, 2023 - mdpi.com
This review considers the chiral phosphorus-containing drugs used to treat patients in the
clinic, as well as the promising and experimental drugs that are in the process of being …
clinic, as well as the promising and experimental drugs that are in the process of being …
Electrocatalytic C–H phosphorylation through nickel (III/IV/II) catalysis
C–H phosphorylation was achieved by Earth-abundant nickel catalysts with waste-free
electricity as the redox surrogate. The robust nickela-electrooxidative C–H activation of …
electricity as the redox surrogate. The robust nickela-electrooxidative C–H activation of …
Synthesis and Reactions of α-Hydroxyphosphonates
Z Rádai, G Keglevich - Molecules, 2018 - mdpi.com
This review summarizes the main synthetic routes towards α-hydroxyphosphonates that are
known as enzyme inhibitors, herbicides and antioxidants, moreover, a number of …
known as enzyme inhibitors, herbicides and antioxidants, moreover, a number of …
Visible-Light-Induced Highly Site-Selective Direct C–H Phosphorylation of Pyrrolo[2,3-d]pyrimidine Derivatives with H-Phosphine Oxides
Z Zhang, M Liu, M Liu, C Pan, Z Mao… - The Journal of Organic …, 2024 - ACS Publications
An efficient and highly regioselective C6-phosphorylation protocol for pyrrolo [2, 3-d]
pyrimidine (7-DAP) derivatives with various H-phosphine oxides induced by visible light at …
pyrimidine (7-DAP) derivatives with various H-phosphine oxides induced by visible light at …
Small molecule substrate phosphorylation site inhibitors of protein kinases: approaches and challenges
ME Breen, MB Soellner - ACS chemical biology, 2015 - ACS Publications
Protein kinases are important mediators of cellular communication and attractive drug
targets for many diseases. Although success has been achieved with developing ATP …
targets for many diseases. Although success has been achieved with developing ATP …
Strategies for the discovery of target-specific or isoform-selective modulators
Currently, the creation of class-and isoform-selective modulators of biologically important
targets is a particularly challenging problem because different isoforms within a protein …
targets is a particularly challenging problem because different isoforms within a protein …
The implication of STEP in synaptic plasticity and cognitive impairments in Alzheimer's disease and other neurological disorders
YAR Mahaman, F Huang, KS Embaye… - Frontiers in Cell and …, 2021 - frontiersin.org
STriatal-Enriched protein tyrosine Phosphatase (STEP) is a tyrosine phosphatase that has
been implicated in Alzheimer's disease (AD), the most common form of dementia, and many …
been implicated in Alzheimer's disease (AD), the most common form of dementia, and many …