Advances on the merger of electrochemistry and transition metal catalysis for organic synthesis

CA Malapit, MB Prater, JR Cabrera-Pardo, M Li… - Chemical …, 2021 - ACS Publications
Synthetic organic electrosynthesis has grown in the past few decades by achieving many
valuable transformations for synthetic chemists. Although electrocatalysis has been popular …

The role of the phosphorus atom in drug design

JB Rodriguez, C Gallo‐Rodriguez - ChemMedChem, 2019 - Wiley Online Library
Although the phosphorus atom is found in a variety of oxidation states, most of the
phosphorus‐containing molecules of pharmacological importance possess phosphorus in …

Scalable Rhodium (III)‐Catalyzed Aryl C− H Phosphorylation Enabled by Anodic Oxidation Induced Reductive Elimination

ZJ Wu, F Su, W Lin, J Song, TB Wen… - Angewandte …, 2019 - Wiley Online Library
Transition metal catalyzed C− H phosphorylation remains an unsolved challenge. Reported
methods are generally limited in scope and require stoichiometric silver salts as oxidants …

Chiral Organophosphorus Pharmaceuticals: Properties and Application

AO Kolodiazhna, OI Kolodiazhnyi - Symmetry, 2023 - mdpi.com
This review considers the chiral phosphorus-containing drugs used to treat patients in the
clinic, as well as the promising and experimental drugs that are in the process of being …

Electrocatalytic C–H phosphorylation through nickel (III/IV/II) catalysis

SK Zhang, A Del Vecchio, R Kuniyil, AM Messinis, Z Lin… - Chem, 2021 - cell.com
C–H phosphorylation was achieved by Earth-abundant nickel catalysts with waste-free
electricity as the redox surrogate. The robust nickela-electrooxidative C–H activation of …

Synthesis and Reactions of α-Hydroxyphosphonates

Z Rádai, G Keglevich - Molecules, 2018 - mdpi.com
This review summarizes the main synthetic routes towards α-hydroxyphosphonates that are
known as enzyme inhibitors, herbicides and antioxidants, moreover, a number of …

Visible-Light-Induced Highly Site-Selective Direct C–H Phosphorylation of Pyrrolo[2,3-d]pyrimidine Derivatives with H-Phosphine Oxides

Z Zhang, M Liu, M Liu, C Pan, Z Mao… - The Journal of Organic …, 2024 - ACS Publications
An efficient and highly regioselective C6-phosphorylation protocol for pyrrolo [2, 3-d]
pyrimidine (7-DAP) derivatives with various H-phosphine oxides induced by visible light at …

Small molecule substrate phosphorylation site inhibitors of protein kinases: approaches and challenges

ME Breen, MB Soellner - ACS chemical biology, 2015 - ACS Publications
Protein kinases are important mediators of cellular communication and attractive drug
targets for many diseases. Although success has been achieved with developing ATP …

Strategies for the discovery of target-specific or isoform-selective modulators

P Zhan, Y Itoh, T Suzuki, X Liu - Journal of medicinal chemistry, 2015 - ACS Publications
Currently, the creation of class-and isoform-selective modulators of biologically important
targets is a particularly challenging problem because different isoforms within a protein …

The implication of STEP in synaptic plasticity and cognitive impairments in Alzheimer's disease and other neurological disorders

YAR Mahaman, F Huang, KS Embaye… - Frontiers in Cell and …, 2021 - frontiersin.org
STriatal-Enriched protein tyrosine Phosphatase (STEP) is a tyrosine phosphatase that has
been implicated in Alzheimer's disease (AD), the most common form of dementia, and many …