Conspectus The use of quaternary stereocenters during lead candidate optimization
continues to grow because of improved physiochemical and pharmacokinetic profiles of …

Conspectus Transition-metal catalyzed cross-coupling reactions are fundamental reactions
in organic chemistry, facilitating strategic bond formations for accessing natural products …

In this contribution, we provide a comprehensive overview of C–H activation methods
promoted by NHC–transition metal complexes, covering the literature since 2002 (the year …

1, 2-Dicarbofunctionalization of alkenes has emerged as an efficient synthetic strategy for
preparing substituted molecules by coupling readily available alkenes with electrophiles …

Nickel-catalyzed reductive cross-coupling reactions have emerged as powerful methods to
join two electrophiles. These reactions have proven particularly useful for the coupling of sec …

As alcohols are ubiquitous throughout chemical science, this functional group represents a
highly attractive starting material for forging new C–C bonds. Here, we demonstrate that the …

The merger of electrochemistry and transition metal catalysis has emerged as a powerful
tool to join two electrophiles in an enantioselective manner. However, the development of …

Conspectus Nickel complexes exhibit distinct properties from other group 10 metals,
including a small nuclear radius, high paring energy, low electronegativity, and low redox …

Cross-coupling reactions, which were discovered almost 50 years ago, are widely used in
both industry and academia. Even though cross-coupling reactions now represent mature …

Nickel-catalyzed reductive cross-electrophile coupling reactions are becoming increasingly
important in organic synthesis, but application at scale is limited by three interconnected …