Pathogenic mechanisms of human immunodeficiency virus (HIV)-associated pain

X Liu, SJ Tang - Molecular Psychiatry, 2023 - nature.com
Chronic pain is a prevalent neurological complication among individuals living with human
immunodeficiency virus (PLHIV) in the post-combination antiretroviral therapy (cART) era …

HIV-associated neurocognitive disorder: key implications of the microbiota-gut-brain axis

A Hu, SD Zaongo, V Harypursat, X Wang… - Frontiers in …, 2024 - frontiersin.org
HIV-associated neurocognitive disorder (HAND) is now recognized to be relatively common
in people living with HIV (PLWH), and remains a common cause of cognitive impairment …

Effects of acute cannabidiol on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice

BJ Yadav-Samudrala, BL Gorman… - Frontiers in …, 2024 - frontiersin.org
Background Some evidence suggests that cannabidiol (CBD) has potential to help alleviate
HIV symptoms due to its antioxidant and anti-inflammatory properties. Here we examined …

Depressive-like behavior is accompanied by prefrontal cortical innate immune fatigue and dendritic spine losses after HIV-1 tat and morphine exposure

SR Nass, YK Hahn, M Ohene-Nyako, VD McLane… - Viruses, 2023 - mdpi.com
Opioid use disorder (OUD) and HIV are comorbid epidemics that can increase depression.
HIV and the viral protein Tat can directly induce neuronal injury within reward and …

[HTML][HTML] Effects of acute Δ9-tetrahydrocannabinol on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice

BJ Yadav-Samudrala, BL Gorman, H Dodson… - Brain Research, 2024 - Elsevier
Cannabis use is highly prevalent especially among people living with HIV (PLWH).
Activation of the anti-inflammatory and neuroprotective endocannabinoid system by …

Exploring viral neuropathic pain: Molecular mechanisms and therapeutic implications

S Xu, H Li, Z Ai, R Guo, H Cheng, Y Wang - Plos Pathogens, 2024 - journals.plos.org
As the Coronavirus Disease 2019 (COVID-19) pandemic continues, there is a growing
concern regarding the relationship between viral infections and neuropathic pain. Chronic …

Acute Effects of Monoacylglycerol Lipase Inhibitor ABX1431 on Neuronal Hyperexcitability, Nociception, Locomotion, and the Endocannabinoid System in HIV-1 Tat …

BJ Yadav-Samudrala, HP Ravula… - Cannabis and …, 2024 - liebertpub.com
Background: Evidence suggests that monoacylglycerol lipase (MAGL) inhibitors can
potentially treat HIV symptoms by increasing the concentration of 2-arachidonoylglycerol (2 …

Progress in Pathological and Therapeutic research of HIV-related Neuropathic Pain

YL Hu, J Liu, R Zhuang, C Zhang, F Lin, J Wang… - Cellular and Molecular …, 2023 - Springer
HIV-related neuropathic pain (HRNP) is a neurodegeneration that gradually develops
during the long-term course of acquired immune deficiency syndrome (AIDS) and manifests …

The Effects of Phytocannabinoids and HIV-1 Tat on Animal Behavior and Microglia-Mediated Neurotoxicity

B Gorman - 2022 - cdr.lib.unc.edu
Human immunodeficiency virus type-1 (HIV-1) is associated with high rates of cognitive
impairment, anxiety, and pain, likely related to the neuroinflammatory and neurotoxic effects …