Regulation of microRNA biogenesis and its crosstalk with other cellular pathways
T Treiber, N Treiber, G Meister - Nature reviews Molecular cell biology, 2019 - nature.com
MicroRNAs (miRNAs) are short non-coding RNAs that inhibit the expression of target genes
by directly binding to their mRNAs. miRNAs are transcribed as precursor molecules, which …
by directly binding to their mRNAs. miRNAs are transcribed as precursor molecules, which …
The role of non-coding RNAs in oncology
FJ Slack, AM Chinnaiyan - Cell, 2019 - cell.com
For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …
A signature of saliva-derived exosomal small RNAs as predicting biomarker for esophageal carcinoma: a multicenter prospective study
K Li, Y Lin, Y Luo, X Xiong, L Wang, K Durante, J Li… - Molecular cancer, 2022 - Springer
Background The tRNA-derived small RNAs (tsRNAs) are produced in a nuclease-
dependent manner in responses to variety of stresses that are common in cancers. We focus …
dependent manner in responses to variety of stresses that are common in cancers. We focus …
Non-coding RNA networks in cancer
E Anastasiadou, LS Jacob, FJ Slack - Nature Reviews Cancer, 2018 - nature.com
Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the
past decade has altered our perception of ncRNAs from'junk'transcriptional products to …
past decade has altered our perception of ncRNAs from'junk'transcriptional products to …
Emerging roles of tRNA-derived fragments in cancer
M Fu, J Gu, M Wang, J Zhang, Y Chen, P Jiang, T Zhu… - Molecular cancer, 2023 - Springer
Abstract tRNA-derived fragments (tRFs) are an emerging category of small non-coding
RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance …
RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance …
Action mechanisms and research methods of tRNA-derived small RNAs
Y Xie, L Yao, X Yu, Y Ruan, Z Li, J Guo - Signal transduction and …, 2020 - nature.com
Abstract tRNA-derived small RNAs (tsRNAs), including tRNA-derived fragments (tRFs) and
tRNA halves (tiRNAs), are small regulatory RNAs processed from mature tRNAs or …
tRNA halves (tiRNAs), are small regulatory RNAs processed from mature tRNAs or …
The life and times of a tRNA
EM Phizicky, AK Hopper - RNA, 2023 - rnajournal.cshlp.org
The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …
and insights in the last several years. We now have unprecedented knowledge of each step …
Revisiting criteria for plant microRNA annotation in the era of big data
Abstract MicroRNAs (miRNAs) are∼ 21-nucleotide-long regulatory RNAs that arise from
endonucleolytic processing of hairpin precursors. Many function as essential …
endonucleolytic processing of hairpin precursors. Many function as essential …
tRNA fragments (tRFs) guide Ago to regulate gene expression post-transcriptionally in a Dicer-independent manner
tRNA related RNA fragments (tRFs), also known as tRNA-derived RNAs (tdRNAs), are
abundant small RNAs reported to be associated with Argonaute proteins, yet their function is …
abundant small RNAs reported to be associated with Argonaute proteins, yet their function is …
Endogenous tRNA-derived fragments suppress breast cancer progression via YBX1 displacement
Upon exposure to stress, tRNAs are enzymatically cleaved, yielding distinct classes of tRNA-
derived fragments (tRFs). We identify a novel class of tRFs derived from tRNA Glu, tRNA …
derived fragments (tRFs). We identify a novel class of tRFs derived from tRNA Glu, tRNA …