Trends in insulin resistance: insights into mechanisms and therapeutic strategy

M Li, X Chi, Y Wang, S Setrerrahmane… - Signal transduction and …, 2022 - nature.com
The centenary of insulin discovery represents an important opportunity to transform diabetes
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …

Common and novel markers for measuring inflammation and oxidative stress ex vivo in research and clinical practice—which to use regarding disease outcomes?

A Menzel, H Samouda, F Dohet, S Loap, MS Ellulu… - Antioxidants, 2021 - mdpi.com
Many chronic conditions such as cancer, chronic obstructive pulmonary disease, type-2
diabetes, obesity, peripheral/coronary artery disease and auto-immune diseases are …

Scutellaria baicalensis Georgi polysaccharide ameliorates DSS-induced ulcerative colitis by improving intestinal barrier function and modulating gut microbiota

L Cui, X Guan, W Ding, Y Luo, W Wang, W Bu… - International Journal of …, 2021 - Elsevier
The aim of this study was to investigate the effect of a polysaccharide from Scutellaria
baicalensis Georgi on UC. Gut microbiota dysbiosis is a worldwide problem associating with …

The interplay among miRNAs, major cytokines, and cancer-related inflammation

C Chakraborty, AR Sharma, G Sharma… - Molecular Therapy-Nucleic …, 2020 - cell.com
Inflammation is closely related with the progression of cancer and is an indispensable
component that orchestrates the tumor microenvironment. Studies suggest that different …

Metabolic syndrome in children and adolescents

C Wittcopp, R Conroy - Pediatrics in review, 2016 - publications.aap.org
As the prevalence of obesity in adults and youth continues at historically high rates, so does
the occurrence of obesity-related comorbidities. Many chronic diseases that were once …

Occurrence, biological activity and metabolism of 6-shogaol

X Kou, X Wang, R Ji, L Liu, Y Qiao, Z Lou, C Ma, S Li… - Food & function, 2018 - pubs.rsc.org
As one of the main bioactive compounds of dried ginger, 6-shogaol has been widely used to
alleviate many ailments. It is also a major pungent flavor component, and its precursor prior …

Polysaccharide isolated from Phellinus linteus mycelia exerts anti-inflammatory effects via MAPK and PPAR signaling pathways

T Hu, Q Lin, T Guo, T Yang, W Zhou, X Deng… - Carbohydrate …, 2018 - Elsevier
In the present study, the anti-inflammatory function of Phellinus linteus polysaccharide (PLP)
was investigated in animal and cell inflammation models, and the anti-inflammatory …

Curcumin inhibits angiotensin II-induced inflammation and proliferation of rat vascular smooth muscle cells by elevating PPAR-γ activity and reducing oxidative stress

HY Li, M Yang, Z Li, Z Meng - … Journal of Molecular …, 2017 - spandidos-publications.com
Angiotensin II (AngII)-induced production of inflammatory factors and proliferation in
vascular smooth muscle cells (VSMCs) play an important role in the progression of …

Sirt1-PPARS cross-talk in complex metabolic diseases and inherited disorders of the one carbon metabolism

VJ Kosgei, D Coelho, RM Guéant-Rodriguez… - Cells, 2020 - mdpi.com
Sirtuin1 (Sirt1) has a NAD (+) binding domain and modulates the acetylation status of
peroxisome proliferator-activated receptor-γ coactivator-1α (PGC1α) and Fork Head Box O1 …

Shikimic Acid Regulates the NF-κB/MAPK Signaling Pathway and Gut Microbiota to Ameliorate DSS-Induced Ulcerative Colitis

X Li, K Mo, G Tian, J Zhou, J Gong, L Li… - Journal of Agricultural …, 2023 - ACS Publications
Shikimic acid (SA) is a compound extracted from the plant anise and has anti-inflammatory
effects. However, any impact on intestinal inflammation or mechanisms involved has not …