Osteoporosis and its associated fracture risk has become one of the major health burdens in
our aging population. Currently, bisphosphonate, one of the most popular antiresorptive …

Sclerostin is an osteocyte derived negative regulator of bone formation. A highly specific
expression pattern and the exclusive bone phenotype have made Sclerostin an attractive …

Sclerostin, encoded by the SOST gene, works as an inhibitor of the Wnt pathway and
therefore is an important regulator of bone homeostasis. Due to its potent action as an …

The peroxisome proliferator activated receptor gamma (PPARG) nuclear receptor regulates
energy metabolism and insulin sensitivity. In this study, we present novel evidence for an …

Osteoporosis is a systemic skeletal disorder characterized by a decrease in bone mass and
microarchitectural deterioration of bone tissue. The World Health Organization has defined …

Abstract Purpose of Review Novel therapies for damaged and diseased bone are being
developed in a preclinical testing process consisting of in vitro cell experiments followed by …

Sclerostin, a glycoprotein encoded by the SOST gene, is mainly produced by mature
osteocytes and is a critical regulator of bone formation through its inhibitory effect on Wnt …

ABSTRACT X‐linked hypophosphatemia (XLH) is characterized by impaired renal tubular
reabsorption of phosphate owing to increased circulating FGF23 levels, resulting in rickets in …

Osteocytes remodel their surrounding perilacunar matrix and canalicular network to
maintain skeletal homeostasis. Perilacunar/canalicular remodeling is also thought to play a …

We induced chronic kidney disease (CKD) with adenine in WT mice, mice with osteocyte-
specific deletion of Cyp27b1, encoding the 25-hydroxyvitamin D 1 (OH) ase [Oct-1 (OH) ase …