Mechanoinformatics: High-throughput single cell mechanical properties mapping to unravel cell heterogeneity

Q Hu, W Sun, F Lin, C Xiong - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Mechanical properties of cells are not only unique intrinsic labels of cells, but also closely
related to the behaviors and functions of cells under various physiological and pathological …

Critical review of single-cell mechanotyping approaches for biomedical applications

M Chapman, V Rajagopal, A Stewart, DJ Collins - Lab on a Chip, 2024 - pubs.rsc.org
Accurate mechanical measurements of cells has the potential to improve diagnostics,
therapeutics and advance understanding of disease mechanisms, where high-resolution …

Machine learning empowered multi-stress level electromechanical phenotyping for high-dimensional single cell analysis

M Liang, Q Tang, J Zhong, Y Ai - Biosensors and Bioelectronics, 2023 - Elsevier
Microfluidics provides a powerful platform for biological analysis by harnessing the ability to
precisely manipulate fluids and microparticles with integrated microsensors. Here, we …

Intelligent image-based deformability assessment of red blood cells via dynamic shape classification

M Liang, J Zhong, CS Shannon, R Agrawal… - Sensors and Actuators B …, 2024 - Elsevier
Red blood cells (RBC), the primary component of whole blood, play an essential role in
maintaining blood fluidity and mass transport throughout the human body. RBC …

Inertial Multi‐Force Deformability Cytometry for High‐Throughput, High‐Accuracy, and High‐Applicability Tumor Cell Mechanotyping

Y Chen, C Ni, L Jiang, Z Ni, N Xiang - Small, 2024 - Wiley Online Library
Previous on‐chip technologies for characterizing the cellular mechanical properties often
suffer from a low throughput and limited sensitivity. Herein, an inertial multi‐force …

Acoustic‐Based Microbubble Grippers for Automatic On‐Chip Selection of Spherical Microrobot Models

Y Wei, X Lu, J Bao, S Zhang… - Advanced Materials …, 2024 - Wiley Online Library
Spherical micro/nanorobots are reported as attractive candidates in nano‐surgery,
contamination degradation, analytical chemistry, medical engineering, etc. Unlike …

DUPLETS: Deformability‐Assisted Dual‐Particle Encapsulation Via Electrically Activated Sorting

J Zhong, M Liang, Y Ai - Small Methods, 2023 - Wiley Online Library
Co‐encapsulation of bead carriers and biological cells in microfluidics has become a
powerful technique for various biological assays in single‐cell genomics and drug screening …

Viscoelastic-Sorting Integrated Deformability Cytometer for High-Throughput Sorting and High-Precision Mechanical Phenotyping of Tumor Cells

Y Chen, L Jiang, X Zhang, Z Ni, N Xiang - Analytical Chemistry, 2023 - ACS Publications
The counts and phenotypes of circulating tumor cells (CTCs) in whole blood are useful for
disease monitoring and prognostic assessment of cancer. However, phenotyping CTCs in …

Microfluidic characterization of single‐cell biophysical properties and the applications in cancer diagnosis

SS Li, CD Xue, YJ Li, XM Chen, Y Zhao… - Electrophoresis, 2024 - Wiley Online Library
Single‐cell biophysical properties play a crucial role in regulating cellular physiological
states and functions, demonstrating significant potential in the fields of life sciences and …

High‐Throughput Sorting and Single‐Cell Mechanotyping by Hydrodynamic Sorting‐Mechanotyping Cytometry

Y Chen, C Ni, X Zhang, Z Ni, N Xiang - Small Methods, 2024 - Wiley Online Library
The existence of many background blood cells hinders the accurate identification of
circulating tumor cells (CTCs) in the blood of cancer patients. To unlock this limitation, a …