Mechanoinformatics: High-throughput single cell mechanical properties mapping to unravel cell heterogeneity
Q Hu, W Sun, F Lin, C Xiong - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Mechanical properties of cells are not only unique intrinsic labels of cells, but also closely
related to the behaviors and functions of cells under various physiological and pathological …
related to the behaviors and functions of cells under various physiological and pathological …
Critical review of single-cell mechanotyping approaches for biomedical applications
Accurate mechanical measurements of cells has the potential to improve diagnostics,
therapeutics and advance understanding of disease mechanisms, where high-resolution …
therapeutics and advance understanding of disease mechanisms, where high-resolution …
Machine learning empowered multi-stress level electromechanical phenotyping for high-dimensional single cell analysis
Microfluidics provides a powerful platform for biological analysis by harnessing the ability to
precisely manipulate fluids and microparticles with integrated microsensors. Here, we …
precisely manipulate fluids and microparticles with integrated microsensors. Here, we …
Intelligent image-based deformability assessment of red blood cells via dynamic shape classification
Red blood cells (RBC), the primary component of whole blood, play an essential role in
maintaining blood fluidity and mass transport throughout the human body. RBC …
maintaining blood fluidity and mass transport throughout the human body. RBC …
Inertial Multi‐Force Deformability Cytometry for High‐Throughput, High‐Accuracy, and High‐Applicability Tumor Cell Mechanotyping
Y Chen, C Ni, L Jiang, Z Ni, N Xiang - Small, 2024 - Wiley Online Library
Previous on‐chip technologies for characterizing the cellular mechanical properties often
suffer from a low throughput and limited sensitivity. Herein, an inertial multi‐force …
suffer from a low throughput and limited sensitivity. Herein, an inertial multi‐force …
Acoustic‐Based Microbubble Grippers for Automatic On‐Chip Selection of Spherical Microrobot Models
Spherical micro/nanorobots are reported as attractive candidates in nano‐surgery,
contamination degradation, analytical chemistry, medical engineering, etc. Unlike …
contamination degradation, analytical chemistry, medical engineering, etc. Unlike …
DUPLETS: Deformability‐Assisted Dual‐Particle Encapsulation Via Electrically Activated Sorting
Co‐encapsulation of bead carriers and biological cells in microfluidics has become a
powerful technique for various biological assays in single‐cell genomics and drug screening …
powerful technique for various biological assays in single‐cell genomics and drug screening …
Viscoelastic-Sorting Integrated Deformability Cytometer for High-Throughput Sorting and High-Precision Mechanical Phenotyping of Tumor Cells
Y Chen, L Jiang, X Zhang, Z Ni, N Xiang - Analytical Chemistry, 2023 - ACS Publications
The counts and phenotypes of circulating tumor cells (CTCs) in whole blood are useful for
disease monitoring and prognostic assessment of cancer. However, phenotyping CTCs in …
disease monitoring and prognostic assessment of cancer. However, phenotyping CTCs in …
Microfluidic characterization of single‐cell biophysical properties and the applications in cancer diagnosis
Single‐cell biophysical properties play a crucial role in regulating cellular physiological
states and functions, demonstrating significant potential in the fields of life sciences and …
states and functions, demonstrating significant potential in the fields of life sciences and …
High‐Throughput Sorting and Single‐Cell Mechanotyping by Hydrodynamic Sorting‐Mechanotyping Cytometry
Y Chen, C Ni, X Zhang, Z Ni, N Xiang - Small Methods, 2024 - Wiley Online Library
The existence of many background blood cells hinders the accurate identification of
circulating tumor cells (CTCs) in the blood of cancer patients. To unlock this limitation, a …
circulating tumor cells (CTCs) in the blood of cancer patients. To unlock this limitation, a …