Peptide hormones are first produced as larger precursor prohormones that require
endoproteolytic cleavage to liberate the mature hormones. A structurally conserved but …

Recent articles have highlighted the lack of reproducibility of data from scientific
publications. Here we would argue that a better way to describe and also tackle this matter is …

Induction of oral tolerance by vaccination with type 1 diabetes mellitus (T1DM)-associated
autoantigens exhibits great potential in preventing and treating this autoimmune disease …

Optimized insulin therapies, increased use of continuous glucose monitoring/insulin pumps
and most importantly the arrival of reliable closed loop systems will undeniably lead to a …

Antigen-specific immune tolerance, which possesses great potential in preventing or curing
type 1 diabetes mellitus (T1DM), can be induced by oral vaccination with T1DM-related …

Type 1 diabetes is an autoimmune disease in which insulin-secreting β-cells are destroyed,
leading to a lifelong dependency on exogenous insulin. There are no approved disease …

Oral tolerance, induced by oral administration of autoantigens, is a promising therapeutic
approach to treat type 1 diabetes mellitus (T1DM). However, the degradation of antigens …

Autoantigen-specific immunological tolerance represents a central objective for prevention
of type 1 diabetes (T1D). Previous studies demonstrated mucosal antigen administration …

As a T cell-mediated autoimmune disease, type 1 diabetes mellitus (T1DM) is marked by
insulin defect resulting from the destruction of pancreatic β-cells. The understanding of …

Introduction and aims Studies have reported that myeloid differentiation factor 88 (MyD88)
plays an important role in the development of type 1 diabetes (T1D). The aim of this study …