This review covers recent advances in the use of the squaramide moiety in chemical
research. We focus on the varied applications of squaramides under the broad headings of …

Transcription, the first step of gene expression, is carried out by the enzyme RNA
polymerase (RNAP) and is regulated through interaction with a series of protein transcription …

Since its discovery and characterization in the early 1960s (Hurwitz, J. The discovery of RNA
polymerase. J. Biol. Chem. 2005, 280, 42477–42485), an enormous amount of biochemical …

Fidaxomicin is an antibacterial drug in clinical use for treatment of Clostridium difficile
diarrhea. The active ingredient of fidaxomicin, lipiarmycin A3 (Lpm), functions by inhibiting …

Covering: up to the end of 2013 Myxobacteria produce a vast range of structurally diverse
natural products with prominent biological activities. Here, we provide a detailed description …

In this review, we summarize the published data on squaric acid analogues with a special
focus on their use in medicinal chemistry and as potential drugs. Squaric acid is an …

DNA-dependent multisubunit RNA polymerase (RNAP) is the key enzyme of gene
expression and a target of regulation in all kingdoms of life. It is a complex multifunctional …

Streptogramin antibiotics are divided into types A and B, which in combination can act
synergistically. We compared the molecular interactions of the streptogramin combinations …

Gram-negative bacteria provide a particular challenge to antibacterial drug discovery due to
their cell envelope structure. Compound entry is impeded by the lipopolysaccharide (LPS) of …

Squaramides constitute a novel class of RNA polymerase inhibitors of which genetic
evidence and computational modeling previously have suggested an inhibitory mechanism …