Many organs throughout the body maintain epithelial homeostasis by employing a mucosal
barrier which acts as a lubricant and helps to preserve a near-sterile epithelium. Goblet cells …

The ocular surface including the cornea and conjunctiva and its overlying tear film are the
first tissues of the eye to interact with the external environment. The tear film is complex …

The structural and functional integrity of the ocular surface, a continuous epithelial structure
comprised of the cornea, the conjunctiva, and the ductal surface of the lacrimal as well as …

Goblet cell numbers decrease within the conjunctival epithelium in drying and cicatrizing
ocular surface diseases. Factors regulating goblet cell differentiation in conjunctival …

Dry eye disease is a common and multifactorial disease with a high prevalence worldwide.
Water loss, reduced expression of glycocalyx mucins, and loss of goblet cells secreting gel …

Conjunctival goblet cells (CGCs) are specialized cells that produce and secrete soluble
mucins to the tear film that bathes the ocular surface. CGC numbers and functions are …

Purpose: Dupilumab, a monoclonal antibody directed against the interleukin-4 receptor
subunit α (IL-4Rα) of IL-4 and IL-13, is increasingly being used to control atopic disease …

The mucosal glycocalyx of the ocular surface constitutes the point of interaction between the
tear film and the apical epithelial cells. Membrane-associated mucins (MAMs) are the …

The ocular surface—a continuous epithelial surface with regional specializations including
the surface and glandular epithelia of the cornea, conjunctiva, and lacrimal and meibomian …

Purpose: The purpose of this study was to test the hypothesis that KLF4 promotes corneal
epithelial (CE) cell fate by suppressing the epithelial–mesenchymal transition (EMT), using …