Perhexiline: Old Drug, New Tricks? A Summary of Its Anti-Cancer Effects
Cancer metabolic plasticity, including changes in fatty acid metabolism utilisation, is now
widely appreciated as a key driver for cancer cell growth, survival and malignancy. Hence …
widely appreciated as a key driver for cancer cell growth, survival and malignancy. Hence …
Pleiotropic mechanisms of action of perhexiline in heart failure
CH George, AN Mitchell, R Preece… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: The re-purposing of the anti-anginal drug perhexiline (PHX) has resulted in
symptomatic improvements in heart failure (HF) patients. The inhibition of carnitine …
symptomatic improvements in heart failure (HF) patients. The inhibition of carnitine …
The antianginal drug perhexiline displays cytotoxicity against colorectal cancer cells in vitro: a potential for drug repurposing
Simple Summary Cancer cells frequently have an altered metabolism to support their
increased proliferative and invasive activity. Perhexiline, a drug used to treat some …
increased proliferative and invasive activity. Perhexiline, a drug used to treat some …
Stereoselectivity of Electron and Energy Transfer in the Quenching of (S/R)-Ketoprofen-(S)-Tryptophan Dyad Excited State
AA Ageeva, SV Babenko, IM Magin… - International Journal of …, 2020 - mdpi.com
Photoinduced elementary processes in chiral linked systems, consisting of drugs and
tryptophan (Trp) residues, attract considerable attention due to several aspects. First of all …
tryptophan (Trp) residues, attract considerable attention due to several aspects. First of all …
Emerging drugs for the treatment of angina pectoris
CR Chong, GJ Ong, JD Horowitz - Expert opinion on emerging …, 2016 - Taylor & Francis
Introduction: Angina pectoris, or symptomatic myocardial ischaemia, reflects an impairment
of coronary blood flow, and usually a deficiency of available myocardial energetics …
of coronary blood flow, and usually a deficiency of available myocardial energetics …
Development of fluorinated analogues of perhexiline with improved pharmacokinetic properties and retained efficacy
CC Tseng, H Noordali, M Sani, M Madhani… - Journal of Medicinal …, 2017 - ACS Publications
We designed and synthesized perhexiline analogues that have the same therapeutic profile
as the parent cardiovascular drug but lacking its metabolic liability associated with CYP2D6 …
as the parent cardiovascular drug but lacking its metabolic liability associated with CYP2D6 …
Spin effects as a tool to study photoinduced processes in (S/R)-ketoprofen-(S)-N-methylpyrrolidine dyads
N Polyakov, A Ageeva, A Kiryutin… - The Journal of …, 2019 - pubs.aip.org
(S/R)-Ketoprofen (KP) is considered to be the strongest photosensitizer among nonsteroidal
anti-inflammatory drugs. The photosensitizing reactions are caused by a substituted …
anti-inflammatory drugs. The photosensitizing reactions are caused by a substituted …
(+)-(R)-and (−)-(S)-Perhexiline maleate: Enantioselective synthesis and functional studies on Schistosoma mansoni larval and adult stages
Schistosomiasis is a neglected tropical disease mainly affecting the poorest tropical and
subtropical areas of the world with the impressive number of roughly 200 million infections …
subtropical areas of the world with the impressive number of roughly 200 million infections …
Enantioselectivity in the tissue distribution of perhexiline contributes to different effects on hepatic histology and peripheral neural function in rats
G Licari, RW Milne, AA Somogyi… - Pharmacology …, 2018 - Wiley Online Library
Perhexiline, a chiral drug, is a potent antiischemic agent whose clinical utility is limited by
hepatic and neural toxicities. It inhibits mitochondrial carnitine palmitoyltransferase‐1 …
hepatic and neural toxicities. It inhibits mitochondrial carnitine palmitoyltransferase‐1 …