Exploring epigenetic reprogramming during central nervous system infection
Epigenetics involves the study of various modes of adaptable transcriptional regulation,
contributing to cell identity, characteristics, and function. During central nervous system …
contributing to cell identity, characteristics, and function. During central nervous system …
The clinical significance of histone deacetylase-8 in human breast cancer
Recent studies have shown that the histone deacetylase-8 (HDAC8), as one of the HDACs,
regulates the expression and activity of various genes involved in cancer initiation and …
regulates the expression and activity of various genes involved in cancer initiation and …
Production of the SARS-CoV-2 spike protein and its receptor binding domain in plant cell suspension cultures
The COVID-19 pandemic, caused by the worldwide spread of SARS-CoV-2, has prompted
the scientific community to rapidly develop efficient and specific diagnostics and …
the scientific community to rapidly develop efficient and specific diagnostics and …
How Histone Deacetylase Inhibitors Alter the Secondary Metabolites of Botryosphaeria mamane, an Endophytic Fungus Isolated from Bixa orellana
A Triastuti, M Vansteelandt, F Barakat… - Chemistry & …, 2019 - Wiley Online Library
Fungi are talented organisms able to produce several natural products with a wide range of
structural and pharmacological activities. The conventional fungal cultivation used in …
structural and pharmacological activities. The conventional fungal cultivation used in …
Histone deacetylase inhibitor SAHA improves high salinity tolerance associated with hyperacetylation-enhancing expression of ion homeostasis-related genes in …
S He, Y Hao, Q Zhang, P Zhang, F Ji, H Cheng… - International Journal of …, 2020 - mdpi.com
Histone acetylation plays an important role in regulation of chromatin structure and gene
expression in terms of responding to abiotic stresses. Histone acetylation is modulated by …
expression in terms of responding to abiotic stresses. Histone acetylation is modulated by …
Secondary metabolite production in plant cell culture: A new epigenetic frontier
Plant-derived secondary metabolites have many applications as fragrances, food additives,
dyes, and bioactive medicinal compounds. Production of these compounds in plant cell …
dyes, and bioactive medicinal compounds. Production of these compounds in plant cell …
Synthesis and biological effects of small molecule enhancers for improved recombinant protein production in plant cell cultures
Histone deacetylases are involved in chromatin remodelling and thus play a vital role in the
epigenetic regulation of gene expression. HDAC inhibitors alter the acetylation status of …
epigenetic regulation of gene expression. HDAC inhibitors alter the acetylation status of …
Generation of transgenic cell suspension cultures of the model legume Medicago truncatula: a rapid method for Agrobacterium mediated gene transfer
Plant cell suspension cultures are used in basic research and applied biotechnology. In both
cases, the transfer and stable integration of heterologous genes is a required technique …
cases, the transfer and stable integration of heterologous genes is a required technique …
Successful reversal of transgene silencing in Chlamydomonas reinhardtii
R Beauchemin, N Merindol, E Fantino… - Biotechnology …, 2024 - Wiley Online Library
Chlamydomonas reinhardtii has been successfully engineered to produce compounds of
interest following transgene integration and heterologous protein expression. The …
interest following transgene integration and heterologous protein expression. The …
Discovery of novel tetrahydrobenzo [b] thiophene-3-carbonitriles as histone deacetylase inhibitors
The discovery and development of isoform-selective histone deacetylase (HDAC) inhibitor is
a challenging task because of the sequence homology among HDAC enzymes. In the …
a challenging task because of the sequence homology among HDAC enzymes. In the …