Tacrolimus (FK506): safety and applications in reconstructive surgery

TH Tung - Hand, 2010 - journals.sagepub.com
Tacrolimus (FK506) is a macrolide immunosuppressive drug that is approved for the
prevention of allograft rejection. It is a standard component of immunosuppressive regimens …

Melatonin leads to axonal regeneration, reduction in oxidative stress, and improved functional recovery following sciatic nerve injury

Y Kaya, K Savas, L Sarikcioglu, N Yaras… - Current …, 2015 - ingentaconnect.com
Despite recent advances in microsurgical techniques and equipments, recovery of function
following repair of transected nerves often remains suboptimal. Contrary to traumatic injuries …

Tolerance and effects of FK506 (tacrolimus) on nerve regeneration: a pilot study

DQD Phan, F Schuind - Journal of Hand Surgery (European …, 2012 - journals.sagepub.com
In adults, the outcome of nerve suture and nerve autograft remains generally unsatisfactory.
FK506 (tacrolimus), an immunosuppressant drug used in transplantation, has been reported …

FK506 neuroprotection after cavernous nerve injury is mediated by thioredoxin and glutathione redox systems

G Lagoda, Y Xie, SF Sezen… - The journal of sexual …, 2011 - academic.oup.com
Introduction Immunophilin ligands such as FK506 (FK) preserve erectile function (EF)
following cavernous nerve injury (CNI), although the precise mechanisms are unclear. We …

Immunophilin ligands in peripheral nerve regeneration

YB Kandemir, L Sarikcioglu - Folia morphologica, 2015 - journals.viamedica.pl
Immunophilins are a family of receptors for immunosuppressive drugs like cyclosporin A,
FK506, rapamycin and their non-immunosuppressive analogues, which are collectively …

Tacrolimus enhances the recovery of normal laryngeal muscle fibre distribution after reinnervation

P Gorphe, N Guerout, M Birchall… - The Journal of …, 2012 - cambridge.org
Objectives: To assess the recovery of various muscle fibre types in the posterior
cricoarytenoid muscle after laryngeal reinnervation in the rat, and to determine the influence …

Ultrastructural and morphometric alterations to the peripheral nerve following the administration of immunosuppressive agent tacrolimus (FK506)

FT Celikkan, N Hayirli Ozyol, H Nakkas… - Ultrastructural …, 2021 - Taylor & Francis
Tacrolimus, a widely used immunosuppressive drug for preventing graft rejection following
organ transplantation, was reported to develop neurotoxic side effects ranging from mild to …

Effect of FK506 administration in alpha motor neurons after primary and delayed repair of the sciatic nerve

U Özsoy, FB Yıldırım, BM Demirel, A Hızay… - Anatomy, 2016 - dergipark.org.tr
Objectives: FK506 is an effective immunosuppressive drug for treating graft rejection in
transplants patients. However, the neuroregenerative effect of FK506 has been well …

Efeitos do FK-506 na regeneração de nervos após neurorrafia láteo-terminal: estudo em ratos

MIM Dolfini - 2014 - repositorio.unesp.br
A neurorrafia látero-terminal sem lesão do nervo doador representou grande avanço na
área de microcirurgia de nervos periféricos. O coto distal do nervo receptor é suturado na …