Cancer progression often benefits from the selective conditions present in the tumour
microenvironment, such as the presence of cancer-associated fibroblasts (CAFs) …

Abstract p53 functions as a transcription factor involved in cell-cycle control, DNA repair,
apoptosis and cellular stress responses. However, besides inducing cell growth arrest and …

Half of all human cancers lose p53 function by missense mutations, with an unknown
fraction of these containing p53 in a self-aggregated amyloid-like state. Here we show that a …

p53 is an important tumor suppressor gene, which is stimulated by cellular stress like
ionizing radiation, hypoxia, carcinogens, and oxidative stress. Upon activation, p53 leads to …

The evolutionary history of tumor cell populations can be reconstructed from patterns of
genetic alterations. In contrast to stable genetic events, epigenetic states are reversible and …

The metabolism of the non-essential amino acid L-proline is emerging as a key pathway in
the metabolic rewiring that sustains cancer cells proliferation, survival and metastatic …

Despite being the subject of extensive research and clinical trials, neuroblastoma remains a
major therapeutic challenge in pediatric oncology. The p53 protein is a central safeguard …

The heterogeneous nature of acute myeloid leukemia (AML) and its poor prognosis
necessitate therapeutic improvement. Current advances in AML research yield important …

The tumor suppressor p53 has long been known to play a central role in maintaining a
stable genome in the face of toxic insults through its role in promoting cell‐cycle …

The evasion of anti-growth signaling is an important characteristic of cancer cells. In order to
continue to proliferate, cancer cells must somehow uncouple themselves from the many …