Loss of epigenetic suppression of retrotransposons with oncogenic potential in aging mammary luminal epithelial cells
A primary function of DNA methylation in mammalian genomes is to repress transposable
elements (TEs). The widespread methylation loss that is commonly observed in cancer cells …
elements (TEs). The widespread methylation loss that is commonly observed in cancer cells …
A comparison of epigenetic mitotic-like clocks for cancer risk prediction
AE Teschendorff - Genome Medicine, 2020 - Springer
Background DNA methylation changes that accrue in the stem cell pool of an adult tissue in
line with the cumulative number of cell divisions may contribute to the observed variation in …
line with the cumulative number of cell divisions may contribute to the observed variation in …
Map of epigenetic age acceleration: a worldwide analysis
I Yusipov, A Kalyakulina, A Trukhanov… - Ageing Research …, 2024 - Elsevier
We present a systematic analysis of epigenetic age acceleration based on by far the largest
collection of publicly available DNA methylation data for healthy samples (93 datasets, 23 K …
collection of publicly available DNA methylation data for healthy samples (93 datasets, 23 K …
Non-coding 886 (nc886/vtRNA2-1), the epigenetic odd duck – implications for future studies
E Raitoharju, S Rajić, S Marttila - Epigenetics, 2024 - Taylor & Francis
ABSTRACT Non-coding 886 (nc886, vtRNA2–1) is the only human polymorphically
imprinted gene, in which the methylation status is not determined by genetics. Existing …
imprinted gene, in which the methylation status is not determined by genetics. Existing …
Abrupt involution induces inflammation, estrogenic signaling, and hyperplasia linking lack of breastfeeding with increased risk of breast cancer
Background A large collaborative analysis of data from 47 epidemiological studies
concluded that longer duration of breastfeeding reduces the risk of developing breast …
concluded that longer duration of breastfeeding reduces the risk of developing breast …
An improved epigenetic counter to track mitotic age in normal and precancerous tissues
The cumulative number of stem cell divisions in a tissue, known as mitotic age, is thought to
be a major determinant of cancer-risk. Somatic mutational and DNA methylation (DNAm) …
be a major determinant of cancer-risk. Somatic mutational and DNA methylation (DNAm) …
[HTML][HTML] Identification of DNA methylation signature and rules for SARS-CoV-2 associated with age
Background: COVID-19 displays an increased mortality rate and higher risk of severe
symptoms with increasing age, which is thought to be a result of the compromised immunity …
symptoms with increasing age, which is thought to be a result of the compromised immunity …
Application of Novel Breast Biospecimen Cell-Type Adjustment Identifies Shared DNA Methylation Alterations in Breast Tissue and Milk with Breast Cancer–Risk …
Background: DNA methylation patterning is cell-type–specific and altered DNA methylation
is well established to occur early in breast carcinogenesis, affecting non-cancerous …
is well established to occur early in breast carcinogenesis, affecting non-cancerous …
Breast-Specific Molecular Clocks Comprised of ELF5 Expression and Promoter Methylation Identify Individuals Susceptible to Cancer Initiation
A robust breast cancer prevention strategy requires risk assessment biomarkers for early
detection. We show that expression of ELF5, a transcription factor critical for normal …
detection. We show that expression of ELF5, a transcription factor critical for normal …
Age-related DNA methylation in paired normal and tumour breast tissue in Chinese breast cancer patients
Age-related DNA methylation is a potential mechanism contributing to breast cancer
development. Studies of primarily Caucasian women have identified many CpG sites of age …
development. Studies of primarily Caucasian women have identified many CpG sites of age …