Bone tissue engineering in the treatment of bone defects

N Xue, X Ding, R Huang, R Jiang, H Huang, X Pan… - Pharmaceuticals, 2022 - mdpi.com
Bones play an important role in maintaining exercise and protecting organs. Bone defect, as
a common orthopedic disease in clinics, can cause tremendous damage with long treatment …

Bone regeneration strategies: Engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives

A Ho-Shui-Ling, J Bolander, LE Rustom, AW Johnson… - Biomaterials, 2018 - Elsevier
Bone fractures are the most common traumatic injuries in humans. The repair of bone
fractures is a regenerative process that recapitulates many of the biological events of …

Mapping distinct bone marrow niche populations and their differentiation paths

SL Wolock, I Krishnan, DE Tenen, V Matkins… - Cell reports, 2019 - cell.com
The bone marrow microenvironment is composed of heterogeneous cell populations of non-
hematopoietic cells with complex phenotypes and undefined trajectories of maturation …

[HTML][HTML] On the origin and impact of mesenchymal stem cell heterogeneity: new insights and emerging tools for single cell analysis

CM McLeod, RL Mauck - European cells & materials, 2017 - ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs) display substantial cell-to-cell variation. This heterogeneity
manifests among donors, among tissue sources, and within cell populations. Such pervasive …

[HTML][HTML] Stromal-induced epithelial-mesenchymal transition induces targetable drug resistance in acute lymphoblastic leukemia

CS Park, H Yoshihara, Q Gao, C Qu, I Iacobucci… - Cell reports, 2023 - cell.com
The bone marrow microenvironment (BME) drives drug resistance in acute lymphoblastic
leukemia (ALL) through leukemic cell interactions with bone marrow (BM) niches, but the …

Bone healing materials in the treatment of recalcitrant nonunions and bone defects

EC Rodríguez-Merchán - International Journal of Molecular Sciences, 2022 - mdpi.com
The usual treatment for bone defects and recalcitrant nonunions is an autogenous bone
graft. However, due to the limitations in obtaining autogenous bone grafts and the morbidity …

CD99 at the crossroads of physiology and pathology

M Pasello, MC Manara, K Scotlandi - Journal of cell communication and …, 2018 - Springer
CD99 is a cell surface protein with unique features and only partly defined mechanisms of
action. This molecule is involved in crucial biological processes, including cell adhesion …

Nomenclature and heterogeneity: consequences for the use of mesenchymal stem cells in regenerative medicine

A Wilson, A Webster, P Genever - Regenerative Medicine, 2019 - Taylor & Francis
Mesenchymal stem cells (MSCs) are in development for many clinical indications, based
both on 'stem'properties (tissue repair or regeneration) and on signaling repertoire …

Hypoxia preconditioned bone marrow-derived mesenchymal stromal/stem cells enhance myoblast fusion and skeletal muscle regeneration

K Archacka, I Grabowska, B Mierzejewski… - Stem Cell Research & …, 2021 - Springer
Background The skeletal muscle reconstruction occurs thanks to unipotent stem cells, ie,
satellite cells. The satellite cells remain quiescent and localized between myofiber …

Cytotoxicity of different concentrations of three root canal sealers on human mesenchymal stem cells

SA Alsubait, R Al Ajlan, H Mitwalli, N Aburaisi… - Biomolecules, 2018 - mdpi.com
This study assessed the dose-dependent effect on the cytotoxicity of BioRoot RCS (BR) and
Endosequence BC (BC) sealers in human bone marrow mesenchymal stem cells (hMSCs) …