Ever since the brain was identified as an insulin-sensitive organ, evidence has rapidly
accumulated that insulin action in the brain produces multiple behavioral and metabolic …

Alzheimer's disease (AD) is the most common form of dementia in the elderly, and affects
millions of people worldwide. As the number of AD cases continues to increase in both …

Microglial cells consume adenosine triphosphate (ATP) during phagocytosis to clear
neurotoxic β-amyloid in Alzheimer's disease (AD). However, the contribution of energy …

Myelin degeneration and white matter loss resulting from oligodendrocyte (OL) death are
early events in Alzheimer's disease (AD) that lead to cognitive deficits; however, the …

Excessive poly (ADP-ribose)(PAR) polymerase-1 (PARP-1) activation kills cells via a cell-
death process designated “parthanatos” in which PAR induces the mitochondrial release …

Alzheimer's disease (AD) is a devastative neurodegenerative disorder with complex
etiology. Apoptosis, a biological process that plays an essential role in normal physiology to …

Alzheimer's disease (AD) is the 3rd most costly disease and the leading cause of dementia.
It can linger for many years, but ultimately is fatal, the 6th leading cause of death …

Considerable evidence suggests that mitochondrial dysfunction and oxidative stress
contribute to the progression of Alzheimer's disease (AD). We examined the ability of the …

Alzheimer's disease (AD) and diabetes are currently considered among the top threats to
human health worldwide. Intriguingly, a connection between these diseases has been …

The mitochondria of various tissues from mice, naked mole rats (NMRs), and bats possess
two mechanistically similar systems to prevent the generation of mitochondrial reactive …