Human structural congenital malformations are the leading cause of infant mortality in the
United States. Estimates from the United States Center for Disease Control and Prevention …

Development of effective targeted cancer therapies is fundamentally limited by our
molecular understanding of disease pathogenesis. Diffuse intrinsic pontine glioma (DIPG) is …

The neural tube is the first critically important structure that develops in the embryo. It serves
as the primordium of the central nervous system; therefore, the proper formation of the …

Regulation of chromatin states involves the dynamic interplay between different histone
modifications to control gene expression. Recent advances have enabled mapping of …

Cilia assembly is under strict transcriptional control during animal development. In
vertebrates, a hierarchy of transcription factors (TFs) are involved in controlling the …

Despite recent advances in single-cell genomics, the lack of maps for single-cell candidate
cis-regulatory elements (cCREs) in non-mammal species has limited our exploration of …

The zebrafish Danio rerio is a valuable and common model for scientists in the fields of
genetics and developmental biology. Since zebrafish are also amenable to genetic …

Simple Summary Melanotic neuroectodermal tumor of infancy (MNTI) is a rare tumor of
uncertain origin, morphologically overlapping other rare neoplasms such as pineal anlage …

Pediatric high-grade gliomas (pHGGs) are a deadly and heterogenous subgroup of gliomas
for which the development of innovative treatments is urgent. Advances in high-throughput …

Simple Summary Diffuse midline glioma (DMG), especially diffuse intrinsic pontine glioma
(DIPG), is a deadly pediatric brain tumor that is difficult to diagnose and lacks any real …