Renal drug transporters and drug interactions
Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …
Furthermore, the molecular mechanisms of tubular secretion have been progressively …
Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy
Organic cation transporters (OCTs) of the solute carrier family (SLC) 22 and multidrug and
toxin extrusion (MATE) transporters of the SLC47 family have been identified as uptake and …
toxin extrusion (MATE) transporters of the SLC47 family have been identified as uptake and …
Antiviral drug-induced nephrotoxicity
H Izzedine, V Launay-Vacher, G Deray - American journal of kidney …, 2005 - Elsevier
Drug-induced kidney injury is a major side effect in clinical practice, frequently leading to
acute renal failure (ARF). It accounts for more than 2% to 15% of cases of ARF in patients …
acute renal failure (ARF). It accounts for more than 2% to 15% of cases of ARF in patients …
Clinical pharmacokinetics of lamivudine
MA Johnson, KHP Moore, GJ Yuen, A Bye… - Clinical …, 1999 - Springer
Abstract Lamivudine (3TC), the negative enantiomer of 2′-deoxy-3′-thiacytidine, is a
dideoxynucleoside analogue used in combination with other agents in the treatment of …
dideoxynucleoside analogue used in combination with other agents in the treatment of …
Clinical aspects of transporter‐mediated drug–drug interactions
Drug transporters play an essential role in disposition and effects of multiple drugs. Plasma
concentrations of the victim drug can be modified by drug–drug interactions occurring in …
concentrations of the victim drug can be modified by drug–drug interactions occurring in …
Interactions among drugs for HIV and opportunistic infections
SC Piscitelli, KD Gallicano - New England Journal of Medicine, 2001 - Mass Medical Soc
Drug interactions are an important factor in the treatment of patients with human
immunodeficiency virus (HIV) infection. The complexity of current drug regimens for such …
immunodeficiency virus (HIV) infection. The complexity of current drug regimens for such …
SLC family transporters
X Liu - Drug transporters in drug disposition, effects and …, 2019 - Springer
Solute carrier (SLC) family transporters utilize an electrochemical potential difference or an
ion gradient generated by primary active transporters for transporting their substrates across …
ion gradient generated by primary active transporters for transporting their substrates across …
Update on drug-drug interaction at organic cation transporters: mechanisms, clinical impact, and proposal for advanced in vitro testing
H Koepsell - Expert Opinion on Drug Metabolism & Toxicology, 2021 - Taylor & Francis
Introduction: Organic cation transporters collectively called OCTs belong to three gene
families (SLC22A1 OCT1, SLC22A2 OCT2, SLC22A3 OCT3, SLC22A4 OCTN1, SLC22A5 …
families (SLC22A1 OCT1, SLC22A2 OCT2, SLC22A3 OCT3, SLC22A4 OCTN1, SLC22A5 …
Lamivudine: a review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV infection
CM Perry, D Faulds - Drugs, 1997 - Springer
Synopsis Lamivudine is a dideoxynucleoside analogue which undergoes intracellular
phosphorylation to the putative active metabolite, lamivudine triphosphate. Lamivudine …
phosphorylation to the putative active metabolite, lamivudine triphosphate. Lamivudine …
Relevance of the organic cation transporters 1 and 2 for antiretroviral drug therapy in human immunodeficiency virus infection
N Jung, C Lehmann, A Rubbert, M Knispel… - Drug Metabolism and …, 2008 - ASPET
Carrier-mediated transport across cell membranes is an important determinant of activity,
resistance, and toxicity of chemotherapeutic agents including antiretroviral (ARV) drugs …
resistance, and toxicity of chemotherapeutic agents including antiretroviral (ARV) drugs …