The review highlights the hydantoin syntheses presented from the point of view of the
preparation methods. Novel synthetic routes to various hydantoin structures, the advances …

Inflammasomes are high molecular weight complexes that sense and react to injury and
infection. Their activation induces caspase-1 activation and release of interleukin-1β, a pro …

Enzyme activity alterations have been associated with many metabolism disorders and have
crucial roles in the pathogenesis of some diseases. Tyrosinase is a key enzyme in melanin …

Neuropathic Pain (NPP) is caused by direct or indirect damage to the nervous system and is
a common symptom of many diseases. Clinically, drugs are usually used to suppress pain …

Tamoxifen (TAM) is the standard anti-hormonal therapy for estrogen receptor-positive breast
cancer. However, long-term TAM therapy can make acquisition of TAM resistance and there …

Most pharmaceutical companies test their discovery-stage proprietary molecules in a battery
of in vitro pharmacology assays to try to determine off-target interactions. During all phases …

Purinergic signalling in the brain is becoming an important focus in the study of CNS health
and disease. Various purinergic receptors are found to be present in different brain cells in …

Comprehensive Summary Herein, we report an iridium‐catalyzed asymmetric
hydrogenation of hydantoin and thiazolidinedione derived exocyclic alkenes using our …

The P2X7 purinergic receptor, a calcium permeable cationic channel, is activated by
extracellular ATP. Most studies show that P2X7 receptor plays an important role in the …

Pyridyloxy-directed Rh (III)-catalyzed regioselective C3Ar–H alkenylation of protected
tyrosines was achieved with N-aryl and N-alkyl maleimides, furnishing a series of maleimide …