Protecting group chemistry for the cysteine thiol group has enabled a vast array of peptide
and protein chemistry over the last several decades. Increasingly sophisticated strategies for …

At its basic conceptualization, photoclick chemistry embodies a collection of click reactions
that are performed via the application of light. The emergence of this concept has had …

The prenylation of peptides and proteins is an important post-translational modification
observed in vivo. We report that the Pd-catalyzed Tsuji–Trost allylation with a …

Site-specific incorporation of non-canonical amino acids (ncAAs) into proteins has emerged
as a universal tool for systems bioengineering at the interface of chemistry, biology, and …

Over 20 years ago, the pyrrolysine encoding translation system was discovered in specific
archaea. Our Review provides an overview of how the once obscure pyrrolysyl-tRNA …

Introducing non-canonical amino acids (ncAAs) by engineered orthogonal pairs of
aminoacyl-tRNA synthetases and tRNAs has proven to be a highly useful tool for the …

Post‐translational modifications regulate protein structure and function. Lysine benzoylation
is a newly discovered histone modification with unique physiological relevance. To construct …

Chemists have been interested in the N-alkylation of a peptide bond because such a
modification alters the conformation of the amide bond, interferes with hydrogen bond …

Streptococcus pneumoniae (Pneumococcus) infections affect millions of people worldwide,
cause serious mortality and represent a major economic burden. Despite recent successes …

From about 1750 onwards, the study of proteins/enzymes was one of the main targets of
physiological chemists. 4 SUMNER performed one of the most crucial experiments for …