Preclinical models of medication-related osteonecrosis of the jaw (MRONJ)

JI Aguirre, EJ Castillo, DB Kimmel - Bone, 2021 - Elsevier
Medication-related osteonecrosis of the jaw (MRONJ) is a potentially severe adverse event
affecting patients with cancer and patients with osteoporosis who have been treated with …

Medication-Related Osteonecrosis: Why the Jawbone?

S Kuehn, R Scariot, M Elsalanty - Dentistry Journal, 2023 - mdpi.com
Medication-related osteonecrosis of the jaw (MRONJ) has emerged as a complication of anti-
resorptive medications. Despite its low incidence rate, this problem has gained attention in …

Rodents as an animal model for studying tooth extraction-related medication-related osteonecrosis of the jaw: assessment of outcomes

H Hadad, HR Matheus, SI Pai, FA Souza… - Archives of Oral …, 2024 - Elsevier
Objective To assess the outcomes of several rodent animal models for studying tooth
extraction-related medication-related osteonecrosis of the jaw (MRONJ). Design After a …

[HTML][HTML] The effect of drug holiday on preventing medication-related osteonecrosis of the jaw in osteoporotic rat model

W Zhu, W Yang, L Wang, X Lan, Z Tao, J Guo… - Journal of Orthopaedic …, 2023 - Elsevier
Background Medication-related osteonecrosis of the jaw (MRONJ) is a severe complication
associated with antiresorptive medications managing osteoporosis, such as …

Medication‐related osteonecrosis of the jaw‐like lesions in rodents: a comprehensive systematic review and meta‐analysis

S Kuroshima, M Sasaki, H Murata, T Sawase - Gerodontology, 2019 - Wiley Online Library
Objective The aim of this comprehensive systematic review and meta‐analysis was to
investigate the pathology and pathogenesis of medication‐related osteonecrosis of the jaw …

Introducing a protocol to create bisphosphonate-related osteonecrosis of the jaw in rat animal model

M Zandi, A Dehghan, H Malekzadeh, P Janbaz… - Journal of Cranio …, 2016 - Elsevier
Objective Previously published animal investigations on bisphosphonate-related
osteonecrosis of the jaws (BRONJ) showed a variety of methods for BRONJ induction and …

Antiresorptive-type and discontinuation-timing affect ONJ burden

D Hadaya, A Soundia, I Gkouveris… - Journal of Dental …, 2021 - journals.sagepub.com
Osteonecrosis of the jaws (ONJ), a severe side effect of antiresorptive medications, is
characterized by exposed, nonhealing bone in the oral cavity. Treatment options for ONJ …

Effects of pre-extraction intermittent PTH administration on extraction socket healing in bisphosphonate administered ovariectomized rats

JY Kim, HW Jang, JI Kim, IH Cha - Scientific reports, 2021 - nature.com
The purpose of this study was to investigate the effect of administering intermittent
parathyroid hormone (iPTH) before tooth extraction versus after tooth extraction on the risk of …

The starting point for bisphosphonate-related osteonecrosis of the jaw: Alveolar bone or oral mucosa? A randomized, controlled experimental study

M Zandi, A Dehghan, P Janbaz, H Malekzadeh… - Journal of Cranio …, 2017 - Elsevier
Objective Although over a decade has passed since first introduction of BRONJ, the exact
pathophysiology of this disease is still unclear. The present experimental study aimed to …

Free flap reconstruction for patients with bisphosphonate related osteonecrosis of the jaws after mandibulectomy

T Mücke, M Jung, S Koerdt, DA Mitchell… - Journal of Cranio …, 2016 - Elsevier
Introduction Bisphosphonate related osteonecrosis of the jaws (BRONJ) is a recognised
unwanted effect of these drugs which affect bone remodelling. Treatment options range from …