Immunogenic cell death inducing metal complexes for cancer therapy

L Zhang, N Montesdeoca, J Karges… - Angewandte Chemie …, 2023 - Wiley Online Library
Cancer is one of the deadliest diseases worldwide. Recent statistics have shown that
metastases and tumor relapse are the leading causes of cancer‐associated deaths. While …

Metal-based anticancer agents as immunogenic cell death inducers: the past, present, and future

S Sen, M Won, MS Levine, Y Noh… - Chemical Society …, 2022 - pubs.rsc.org
Cancer is the deadliest disease in the world behind heart disease. Sadly, this remains true
even as we suffer the ravages of the Covid-19 pandemic. Whilst current chemo-and …

An ER‐targeting iridium (III) complex that induces immunogenic cell death in non‐small‐cell lung cancer

L Wang, R Guan, L Xie, X Liao, K Xiong… - Angewandte …, 2021 - Wiley Online Library
Immunogenic cell death (ICD) is a vital component of therapeutically induced anti‐tumor
immunity. An iridium (III) complex (Ir1), containing an N, N‐bis (2‐chloroethyl)‐azane …

At the crossroads of immunotherapy for oncogene-addicted subsets of NSCLC

I Otano, AC Ucero, J Zugazagoitia… - Nature reviews Clinical …, 2023 - nature.com
Non-small-cell lung cancer (NSCLC) has become a paradigm of precision medicine, with
the discovery of numerous disease subtypes defined by specific oncogenic driver mutations …

Trial watch: chemotherapy-induced immunogenic cell death in oncology

J Sprooten, RS Laureano, I Vanmeerbeek… - …, 2023 - Taylor & Francis
Immunogenic cell death (ICD) refers to an immunologically distinct process of regulated cell
death that activates, rather than suppresses, innate and adaptive immune responses. Such …

Target profiling of an iridium (III)-based immunogenic cell death inducer unveils the engagement of unfolded protein response regulator BiP

X Xiong, KB Huang, Y Wang, B Cao… - Journal of the …, 2022 - ACS Publications
Clinical chemotherapeutic drugs have occasionally been observed to induce antitumor
immune responses beyond the direct cytotoxicity. Such effects are coined as immunogenic …

Upregulating aggregation‐induced‐emission nanoparticles with blood–tumor‐barrier permeability for precise photothermal eradication of brain tumors and induction …

M Zhang, W Wang, M Mohammadniaei… - Advanced …, 2021 - Wiley Online Library
Compared to other tumors, glioblastoma (GBM) is extremely difficult to treat. Recently,
photothermal therapy (PTT) has demonstrated advanced therapeutic efficacy; however …

Potent Zinc(II)-Based Immunogenic Cell Death Inducer Triggered by ROS-Mediated ERS and Mitochondrial Ca2+ Overload

LS Liao, Y Chen, C Hou, YH Liu, GF Su… - Journal of Medicinal …, 2023 - ACS Publications
Zn1 and Zn2 are Zn-based complexes that activate the immunogenic cell death (ICD) effect
by Ca2+-mediated endoplasmic reticulum stress (ERS) and mitochondrial dysfunction …

Necroptosis-dependent immunogenicity of cisplatin: implications for enhancing the radiation-induced abscopal effect

R Luo, K Onyshchenko, L Wang, S Gaedicke… - Clinical Cancer …, 2023 - AACR
Purpose: Cisplatin is increasingly used in chemoimmunotherapy and may enhance the T
cell–dependent radiation-induced abscopal effect, but how it promotes antitumor immunity is …

Macrophages as a potential immunotherapeutic target in solid cancers

AK Mishra, S Banday, R Bharadwaj, A Ali, R Rashid… - Vaccines, 2022 - mdpi.com
The revolution in cancer immunotherapy over the last few decades has resulted in a
paradigm shift in the clinical care of cancer. Most of the cancer immunotherapeutic regimens …