Ceramides in Alzheimer's Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Aβ Accumulation

M Jazvinšćak Jembrek, PR Hof… - Oxidative medicine and …, 2015 - Wiley Online Library
Alzheimer's disease (AD), the most common chronic and progressive neurodegenerative
disorder, is characterized by extracellular deposits of amyloid β‐peptides (Aβ) and …

Anti-oxidative, anti-inflammatory and anti-apoptotic effects of flavonols: targeting Nrf2, NF-κB and p53 pathways in neurodegeneration

M Jazvinšćak Jembrek, N Oršolić, L Mandić, A Sadžak… - Antioxidants, 2021 - mdpi.com
Neurodegenerative diseases are one of the leading causes of disability and death
worldwide. Intracellular transduction pathways that end in the activation of specific …

Metal ions influx is a double edged sword for the pathogenesis of Alzheimer's disease

P Wang, ZY Wang - Ageing Research Reviews, 2017 - Elsevier
Alzheimer's disease (AD) is a common form of dementia in aged people, which is defined by
two pathological characteristics: β-amyloid protein (Aβ) deposition and tau …

Ferroptosis and its role in skeletal muscle diseases

Y Wang, Z Zhang, W Jiao, Y Wang, X Wang… - Frontiers in molecular …, 2022 - frontiersin.org
Ferroptosis is characterized by the accumulation of iron and lipid peroxidation products,
which regulates physiological and pathological processes in numerous organs and tissues …

Antioxidative and anti-inflammatory activities of chrysin and naringenin in a drug-induced bone loss model in rats

N Oršolić, J Nemrava, Ž Jeleč, M Kukolj… - International journal of …, 2022 - mdpi.com
Oxidative stress (OS) mediators, together with the inflammatory processes, are considered
as threatening factors for bone health. The aim of this study was to investigate effects of …

Membrane of Candida albicans as a target of berberine

N Zorić, I Kosalec, S Tomić, I Bobnjarić, M Jug… - … and alternative medicine, 2017 - Springer
Background We investigated the mechanisms of anti-Candida action of isoquinoline alkaloid
berberine, active constituent of medically important plants of Barberry species. Methods The …

The role of copper in tau-related pathology in Alzheimer's disease

K Zubčić, PR Hof, G Šimić… - Frontiers in molecular …, 2020 - frontiersin.org
All tauopathies, including Alzheimer's disease (AD), are characterized by the intracellular
accumulation of abnormal forms of tau protein in neurons and glial cells, which negatively …

Chemodynamic therapy agents Cu (II) complexes of quinoline derivatives induced ER stress and mitochondria-mediated apoptosis in SK-OV-3 cells

WY Shen, CP Jia, AN Mo, H Liang, ZF Chen - European Journal of …, 2021 - Elsevier
Three Cu (II) complexes of quinoline derivatives as cancer chemodynamic therapy agents
were synthesized and characterized. These complexes were heavily taken up by cells and …

Role of zinc and copper ions in the pathogenetic mechanisms of traumatic brain injury and Alzheimer's disease

NK Isaev, EV Stelmashook… - Reviews in the …, 2020 - degruyter.com
The disruption of homeostasis of zinc (Zn2+) and copper (Cu2+) ions in the central nervous
system is involved in the pathogenesis of many neurodegenerative diseases, such as …

PI3K/Akt and ERK1/2 Signalling Are Involved in Quercetin‐Mediated Neuroprotection against Copper‐Induced Injury

K Zubčić, V Radovanović, J Vlainić… - Oxidative medicine …, 2020 - Wiley Online Library
Copper, a transition metal with essential cellular functions, exerts neurotoxic effects when
present in excess by promoting production of reactive oxygen species (ROS). The aim of the …