Ceramides in Alzheimer's Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Aβ Accumulation
M Jazvinšćak Jembrek, PR Hof… - Oxidative medicine and …, 2015 - Wiley Online Library
Alzheimer's disease (AD), the most common chronic and progressive neurodegenerative
disorder, is characterized by extracellular deposits of amyloid β‐peptides (Aβ) and …
disorder, is characterized by extracellular deposits of amyloid β‐peptides (Aβ) and …
Anti-oxidative, anti-inflammatory and anti-apoptotic effects of flavonols: targeting Nrf2, NF-κB and p53 pathways in neurodegeneration
Neurodegenerative diseases are one of the leading causes of disability and death
worldwide. Intracellular transduction pathways that end in the activation of specific …
worldwide. Intracellular transduction pathways that end in the activation of specific …
Metal ions influx is a double edged sword for the pathogenesis of Alzheimer's disease
P Wang, ZY Wang - Ageing Research Reviews, 2017 - Elsevier
Alzheimer's disease (AD) is a common form of dementia in aged people, which is defined by
two pathological characteristics: β-amyloid protein (Aβ) deposition and tau …
two pathological characteristics: β-amyloid protein (Aβ) deposition and tau …
Ferroptosis and its role in skeletal muscle diseases
Y Wang, Z Zhang, W Jiao, Y Wang, X Wang… - Frontiers in molecular …, 2022 - frontiersin.org
Ferroptosis is characterized by the accumulation of iron and lipid peroxidation products,
which regulates physiological and pathological processes in numerous organs and tissues …
which regulates physiological and pathological processes in numerous organs and tissues …
Antioxidative and anti-inflammatory activities of chrysin and naringenin in a drug-induced bone loss model in rats
Oxidative stress (OS) mediators, together with the inflammatory processes, are considered
as threatening factors for bone health. The aim of this study was to investigate effects of …
as threatening factors for bone health. The aim of this study was to investigate effects of …
Membrane of Candida albicans as a target of berberine
Background We investigated the mechanisms of anti-Candida action of isoquinoline alkaloid
berberine, active constituent of medically important plants of Barberry species. Methods The …
berberine, active constituent of medically important plants of Barberry species. Methods The …
The role of copper in tau-related pathology in Alzheimer's disease
All tauopathies, including Alzheimer's disease (AD), are characterized by the intracellular
accumulation of abnormal forms of tau protein in neurons and glial cells, which negatively …
accumulation of abnormal forms of tau protein in neurons and glial cells, which negatively …
Chemodynamic therapy agents Cu (II) complexes of quinoline derivatives induced ER stress and mitochondria-mediated apoptosis in SK-OV-3 cells
WY Shen, CP Jia, AN Mo, H Liang, ZF Chen - European Journal of …, 2021 - Elsevier
Three Cu (II) complexes of quinoline derivatives as cancer chemodynamic therapy agents
were synthesized and characterized. These complexes were heavily taken up by cells and …
were synthesized and characterized. These complexes were heavily taken up by cells and …
Role of zinc and copper ions in the pathogenetic mechanisms of traumatic brain injury and Alzheimer's disease
NK Isaev, EV Stelmashook… - Reviews in the …, 2020 - degruyter.com
The disruption of homeostasis of zinc (Zn2+) and copper (Cu2+) ions in the central nervous
system is involved in the pathogenesis of many neurodegenerative diseases, such as …
system is involved in the pathogenesis of many neurodegenerative diseases, such as …
PI3K/Akt and ERK1/2 Signalling Are Involved in Quercetin‐Mediated Neuroprotection against Copper‐Induced Injury
Copper, a transition metal with essential cellular functions, exerts neurotoxic effects when
present in excess by promoting production of reactive oxygen species (ROS). The aim of the …
present in excess by promoting production of reactive oxygen species (ROS). The aim of the …