Biophysical cues play a key role in directing the lineage commitment of mesenchymal stem
cells or multipotent stromal cells (MSC s), but the mechanotransductive mechanisms at play …

Mechanobiology has underpinned many scientific advances in understanding how
biophysical and biomechanical cues regulate cell behavior by identifying mechanosensitive …

The development of hydrogel-based biomaterials represents a promising approach to
generating new strategies for tissue engineering and regenerative medicine. In order to …

Chondrogenically primed bone marrow-derived mesenchymal stem cells (MSCs) have been
shown to become hypertrophic and undergo endochondral ossification when implanted in …

Early osteoarthritis (OA), characterised by cartilage defects, is a degenerative disease that
greatly affects the adult population. Cell-based tissue engineering methods are being …

Biomimetic soft hydrogels used in bone tissue engineering frequently produce unsatisfactory
outcomes. Here, it is investigated how human bone‐marrow‐derived mesenchymal stem …

The objective of this study was to investigate how joint specific biomechanical loading
influences the functional development and phenotypic stability of cartilage grafts engineered …

Both hydrostatic pressure (HP) and cell–matrix interactions have independently been shown
to regulate the chondrogenic differentiation of mesenchymal stem cells (MSCs). The …

This review mainly introduces the types of silk hydrogels, their processing methods, and
applications. There are various methods for hydrogel preparation, and many new processes …

Mechanical stimulation plays in an important role in regulating stem cell differentiation and
their release of extracellular vesicles (EVs). In this study, effects of low magnitude hydrostatic …