Structural investigations of interactions between the influenza a virus NS1 and host cellular proteins
The Influenza A virus is a continuous threat to public health that causes yearly epidemics
with the ever-present threat of the virus becoming the next pandemic. Due to increasing …
with the ever-present threat of the virus becoming the next pandemic. Due to increasing …
Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling
PEAK pseudokinases regulate cell migration, invasion and proliferation by recruiting key
signaling proteins to the cytoskeleton. Despite lacking catalytic activity, alteration in their …
signaling proteins to the cytoskeleton. Despite lacking catalytic activity, alteration in their …
Heterogeneous and allosteric role of surface hydration for protein–ligand binding
Atomistic-level understanding of surface hydration mediating protein–protein interactions
and ligand binding has been a challenge due to the dynamic nature of water molecules near …
and ligand binding has been a challenge due to the dynamic nature of water molecules near …
Molecular recognition of a host protein by NS1 of pandemic and seasonal influenza A viruses
The 1918 influenza A virus (IAV) caused the most severe flu pandemic in recorded human
history. Nonstructural protein 1 (NS1) is an important virulence factor of the 1918 IAV. NS1 …
history. Nonstructural protein 1 (NS1) is an important virulence factor of the 1918 IAV. NS1 …
[PDF][PDF] La pandemia de Gripe de 1918: Mitos y realidades desde la literatura científica
MJM Estévez, RD Álvarez… - Journal of Negative and No …, 2018 - dialnet.unirioja.es
La pandemia de la Gripe de 1918 es la mayor catástrofe sanitaria de la historia.
Aprovechando la celebración de su centenario, comprender este episodio del pasado …
Aprovechando la celebración de su centenario, comprender este episodio del pasado …
Molecular mechanisms of tight binding through fuzzy interactions
Many intrinsically disordered proteins (IDPs) form fuzzy complexes upon binding to their
targets. Although many IDPs are weakly bound in fuzzy complexes, some IDPs form high …
targets. Although many IDPs are weakly bound in fuzzy complexes, some IDPs form high …
Molecular Basis of the Ternary Interaction between NS1 of the 1918 Influenza A Virus, PI3K, and CRK
The 1918 influenza A virus (IAV) caused the worst flu pandemic in human history. Non-
structural protein 1 (NS1) is an important virulence factor of the 1918 IAV and antagonizes …
structural protein 1 (NS1) is an important virulence factor of the 1918 IAV and antagonizes …
Entropy hotspots for the binding of intrinsically disordered ligands to a receptor domain
Proline-rich motifs (PRMs) are widely used for mediating protein-protein interactions with
weak binding affinities. Because they are intrinsically disordered when unbound …
weak binding affinities. Because they are intrinsically disordered when unbound …
A disordered encounter complex is central to the yeast Abp1p SH3 domain binding pathway
GJ Gerlach, R Carrock, R Stix, EJ Stollar… - PLoS Computational …, 2020 - journals.plos.org
Protein-protein interactions are involved in a wide range of cellular processes. These
interactions often involve intrinsically disordered proteins (IDPs) and protein binding …
interactions often involve intrinsically disordered proteins (IDPs) and protein binding …
How a highly acidic SH3 domain folds in the absence of its charged peptide target
V Jaramillo‐Martinez, MJ Dominguez, GM Bell… - Protein …, 2023 - Wiley Online Library
Charged residues on the surface of proteins are critical for both protein stability and
interactions. However, many proteins contain binding regions with a high net charge that …
interactions. However, many proteins contain binding regions with a high net charge that …