Microglia are the brain's resident macrophages, which guide various developmental
processes crucial for brain maturation, activity, and plasticity. Microglial progenitors enter the …

Since the beautiful images of Santiago Ramón y Cajal provided a first glimpse into the
immense diversity and complexity of cell types found in the cerebral cortex, neuroscience …

Cortical circuits are composed predominantly of pyramidal-to-pyramidal neuron
connections, yet their assembly during embryonic development is not well understood. We …

The molecular mechanisms and evolutionary changes accompanying synapse development
are still poorly understood,. Here we generate a cross-species proteomic map of synapse …

In the mouse embryonic forebrain, developmentally distinct oligodendrocyte progenitor cell
populations and their progeny, oligodendrocytes, emerge from three distinct regions in a …

The brain is composed of multiple regions associated with distinct functions, which have
become further specialized in the human lineage. To define how this specialization is …

Mutations in human nonsense-mediated mRNA decay (NMD) factors are enriched in
neurodevelopmental disorders. We show that deletion of key NMD factor Upf2 in mouse …

Neuroscience research has entered a phase of key discoveries in the realm of
neurogenomics owing to strong financial and intellectual support for resource building and …

Developmental neurogenesis is a tightly regulated spatiotemporal process with its
dysregulation implicated in neurodevelopmental disorders. NMDA receptors are glutamate …

Droplet microfluidics-based single-cell encapsulation is a critical technology that enables
large-scale parallel single-cell analysis by capturing and processing thousands of individual …