Unusual amino acids are fundamental building blocks of modern medicinal chemistry. The
combination of readily functionalized amine and carboxyl groups attached to a chiral central …

Metabotropic (G-protein-coupled) glutamate (mGlu) receptors have now emerged as a
recognized, but still relatively new area of excitatory amino acid research. Current …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

While the cyclopropane ring is a highly strained entity, it is nonetheless found in a wide
variety of naturally occurring compounds including terpenes, pheromones, fatty acid …

Glutamate is the primary excitatory neurotransmitter in the brain and plays critical roles in all
aspects of neuronal function. Disruption of normal glutamate transmission has been …

The in vitro pharmacology of a structurally novel compound, LY341495, was investigated at
human recombinant metabotropic glutamate (mGlu) receptor subtypes expressed in non …

Kynurenic acid is a tryptophan metabolite provided with antagonist activity on ionotropic
glutamate and α7 nicotinic acetylcholine receptors. We noticed that in rats with a dialysis …

By a sidearm approach, camphor-derived sulfur ylides 1 were designed and synthesized for
the cyclopropanation of electron-deficient alkenes and epoxidation of aldehydes. Under the …

In a previous study we reported that the addition of a carboxylic group to the mGlu receptor
agonist aminocyclopentane-1, 3-dicarboxylate (ACPD) changes its properties from agonist …

A newly designed chiral sulfonium allylide, generated in situ from the corresponding
sulfonium salt in the presence of KOBut, reacted with α, β-unsaturated esters, ketones …