Targeting hypoxic tumor microenvironment in pancreatic cancer
J Tao, G Yang, W Zhou, J Qiu, G Chen, W Luo… - Journal of hematology & …, 2021 - Springer
Attributable to its late diagnosis, early metastasis, and poor prognosis, pancreatic cancer
remains one of the most lethal diseases worldwide. Unlike other solid tumors, pancreatic …
remains one of the most lethal diseases worldwide. Unlike other solid tumors, pancreatic …
The integrated stress response
In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway,
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …
NUPR1 is a critical repressor of ferroptosis
Ferroptosis is a type of iron-dependent regulated cell death, representing an emerging
disease-modulatory mechanism. Transcription factors play multiple roles in ferroptosis …
disease-modulatory mechanism. Transcription factors play multiple roles in ferroptosis …
[HTML][HTML] Targeting the integrated stress response in cancer therapy
X Tian, S Zhang, L Zhou, AA Seyhan… - Frontiers in …, 2021 - frontiersin.org
The integrated stress response (ISR) is an evolutionarily conserved intra-cellular signaling
network which is activated in response to intrinsic and extrinsic stresses. Various stresses …
network which is activated in response to intrinsic and extrinsic stresses. Various stresses …
Regulation and function of autophagy in pancreatic cancer
Oncogenic KRAS mutation-driven pancreatic ductal adenocarcinoma is currently the fourth-
leading cause of cancer-related deaths in the United States. Macroautophagy (hereafter …
leading cause of cancer-related deaths in the United States. Macroautophagy (hereafter …
[HTML][HTML] Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer
J Swierczynski, A Hebanowska… - World journal of …, 2014 - ncbi.nlm.nih.gov
There is growing evidence that metabolic alterations play an important role in cancer
development and progression. The metabolism of cancer cells is reprogrammed in order to …
development and progression. The metabolism of cancer cells is reprogrammed in order to …
Identification of a drug targeting an intrinsically disordered protein involved in pancreatic adenocarcinoma
Intrinsically disordered proteins (IDPs) are prevalent in eukaryotes, performing signaling and
regulatory functions. Often associated with human diseases, they constitute drug …
regulatory functions. Often associated with human diseases, they constitute drug …
[HTML][HTML] From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypes
HO Byun, YK Lee, JM Kim, G Yoon - BMB reports, 2015 - ncbi.nlm.nih.gov
Cellular senescence is a process by which cells enter a state of permanent cell cycle arrest.
It is commonly believed to underlie organismal aging and age-associated diseases …
It is commonly believed to underlie organismal aging and age-associated diseases …
MiRNA-30a-mediated autophagy inhibition sensitizes renal cell carcinoma cells to sorafenib
B Zheng, H Zhu, D Gu, X Pan, L Qian, B Xue… - Biochemical and …, 2015 - Elsevier
Chemotherapy-induced autophagy activation often contributes to cancer resistance. MiRNA-
30a (miR-30a) is a potent inhibitor of autophagy by downregulating Beclin-1. In this study …
30a (miR-30a) is a potent inhibitor of autophagy by downregulating Beclin-1. In this study …
Aurora kinase A in gastrointestinal cancers: time to target
A Katsha, A Belkhiri, L Goff, W El-Rifai - Molecular cancer, 2015 - Springer
Gastrointestinal (GI) cancers are a major cause of cancer-related deaths. During the last two
decades, several studies have shown amplification and overexpression of Aurora kinase A …
decades, several studies have shown amplification and overexpression of Aurora kinase A …