Attributable to its late diagnosis, early metastasis, and poor prognosis, pancreatic cancer
remains one of the most lethal diseases worldwide. Unlike other solid tumors, pancreatic …

In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway,
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …

Ferroptosis is a type of iron-dependent regulated cell death, representing an emerging
disease-modulatory mechanism. Transcription factors play multiple roles in ferroptosis …

The integrated stress response (ISR) is an evolutionarily conserved intra-cellular signaling
network which is activated in response to intrinsic and extrinsic stresses. Various stresses …

Oncogenic KRAS mutation-driven pancreatic ductal adenocarcinoma is currently the fourth-
leading cause of cancer-related deaths in the United States. Macroautophagy (hereafter …

There is growing evidence that metabolic alterations play an important role in cancer
development and progression. The metabolism of cancer cells is reprogrammed in order to …

Intrinsically disordered proteins (IDPs) are prevalent in eukaryotes, performing signaling and
regulatory functions. Often associated with human diseases, they constitute drug …

Cellular senescence is a process by which cells enter a state of permanent cell cycle arrest.
It is commonly believed to underlie organismal aging and age-associated diseases …

Chemotherapy-induced autophagy activation often contributes to cancer resistance. MiRNA-
30a (miR-30a) is a potent inhibitor of autophagy by downregulating Beclin-1. In this study …

Gastrointestinal (GI) cancers are a major cause of cancer-related deaths. During the last two
decades, several studies have shown amplification and overexpression of Aurora kinase A …