Chemical synthesis of glycosaminoglycans

M Mende, C Bednarek, M Wawryszyn, P Sauter… - Chemical …, 2016 - ACS Publications
Glycosaminoglycans (GAGs) as one major part of the glycocalyx are involved in many
essential biological cell processes, as well as in many courses of diseases. Because of the …

What is the sugar code?

HJ Gabius, M Cudic, T Diercks, H Kaltner… - …, 2022 - Wiley Online Library
A code is defined by the nature of the symbols, which are used to generate information‐
storing combinations (eg oligo‐and polymers). Like nucleic acids and proteins, oligo‐and …

Exploring functional pairing between surface glycoconjugates and human galectins using programmable glycodendrimersomes

Q Xiao, AK Ludwig, C Romanò… - Proceedings of the …, 2018 - National Acad Sciences
Precise translation of glycan-encoded information into cellular activity depends critically on
highly specific functional pairing between glycans and their human lectin counter receptors …

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2013–2014

DJ Harvey - Mass Spectrometry Reviews, 2018 - Wiley Online Library
This review is the eighth update of the original article published in 1999 on the application of
Matrix‐assisted laser desorption/ionization mass spectrometry (MALDI) mass spectrometry …

Automated glycan assembly of oligo-N-acetyllactosamine and keratan sulfate probes to study virus-glycan interactions

HS Hahm, F Broecker, F Kawasaki, M Mietzsch… - Chem, 2017 - cell.com
Summary Oligo-N-acetyllactosamine (LacNAc) and keratan sulfate (KS) glycans exert
crucial functions in disease-relevant processes, including cancer formation, inflammation …

Orthogonal protecting group strategies in carbohydrate chemistry

K Agoston, H Streicher, P Fuegedi - Tetrahedron: Asymmetry, 2016 - Elsevier
A large number of different sets of orthogonal protecting groups have been developed and
used in carbohydrate chemistry over the last decade. These orthogonal sets are collected …

Synthesis of type-I and type-II lacNAc-repeating oligosaccharides as the backbones of tumor-associated lewis antigens

R Phang, CH Lin - Frontiers in Immunology, 2022 - frontiersin.org
Type-I and Type-II LacNAc are Gal-GlcNAc disaccharides bearing a β1, 3-or β1, 4-linkage
respectively. They exist as the backbones of Lewis antigens that are highly expressed in …

Probing sulfatide-tissue lectin recognition with functionalized glycodendrimersomes

PV Murphy, A Romero, Q Xiao, AK Ludwig, S Jogula… - Iscience, 2021 - cell.com
The small 3-O-sulfated galactose head group of sulfatides, an abundant glycosphingolipid
class, poses the (sphinx-like) riddle on involvement of glycan bridging by tissue lectins …

Teaming up synthetic chemistry and histochemistry for activity screening in galectin-directed inhibitor design

R Roy, Y Cao, H Kaltner, N Kottari, TC Shiao… - Histochemistry and cell …, 2017 - Springer
A hallmark of endogenous lectins is their ability to select a few distinct glycoconjugates as
counterreceptors for functional pairing from the natural abundance of cellular glycoproteins …

Structural insight into the binding of human galectins to corneal keratan sulfate, its desulfated form and related saccharides

MC Miller, C Cai, K Wichapong, S Bhaduri, NLB Pohl… - Scientific reports, 2020 - nature.com
Glycosaminoglycan chains of keratan sulfate proteoglycans appear to be physiologically
significant by pairing with tissue lectins. Here, we used NMR spectroscopy and molecular …