Many ion channels have been described as mechanosensitive according to various criteria.
Most broadly defined, an ion channel is called mechanosensitive if its activity is controlled by …

A transmembrane (TMEM) protein with an unknown function is a type of membrane-
spanning protein expressed in the plasma membrane or the membranes of intracellular …

The membrane protein TMEM150C has been proposed to form a mechanosensitive ion
channel that is required for normal proprioceptor function. Here, we examined whether …

Ion channels are the second largest class of drug targets after G protein-coupled receptors.
In addition to well-recognized ones like voltage-gated Na/K/Ca channels in the heart and …

Ferroptosis is that under the action of ferrous iron or ester oxygenase, unsaturated fatty acids
highly expressed on the cell membrane are catalyzed to undergo lipid peroxidation, thereby …

Mechanotransduction is a strictly regulated process whereby mechanical stimuli, including
mechanical forces and properties, are sensed and translated into biochemical signals …

Mechanically activating (MA) channels transduce numerous physiological functions.
Tentonin 3/TMEM150C (TTN3) confers MA currents with slow inactivation kinetics in somato …

Vasoactive intestinal peptide (VIP), a small neuropeptide composing of 28 amino acids,
functions as a neuromodulator with insulinotropic effect on pancreatic β cells, in which it is of …

Introduction Biphasic insulin secretion is an intrinsic characteristic of the pancreatic islet and
has clinical relevance due to the loss of first-phase in patients with Type 2 diabetes. As it has …

Abstract Protein phosphatase 2A (PP2A) is one of the most common serine/threonine
phosphatases in mammalian cells, and it primarily functions to regulate cell signaling …