Plant-based COVID-19 vaccines: current status, design, and development strategies of candidate vaccines

PM Maharjan, S Choe - Vaccines, 2021 - mdpi.com
The prevalence of the coronavirus disease 2019 (COVID-19) pandemic in its second year
has led to massive global human and economic losses. The high transmission rate and the …

Plant-made pharmaceuticals: exploring studies for the production of recombinant protein in plants and assessing challenges ahead

J Lee, SK Lee, JS Park, KR Lee - Plant Biotechnology Reports, 2023 - Springer
The production of pharmaceutical compounds in plants is attracting increasing attention, as
plant-based systems can be less expensive, safer, and more scalable than mammalian …

A plant-produced SARS-CoV-2 spike protein elicits heterologous immunity in hamsters

E Margolin, G Schäfer, JD Allen, S Gers… - Frontiers in Plant …, 2023 - frontiersin.org
Molecular farming of vaccines has been heralded as a cheap, safe and scalable production
platform. In reality, however, differences in the plant biosynthetic machinery, compared to …

Plant-based expression platforms to produce high-value metabolites and proteins

A Kulshreshtha, S Sharma, CS Padilla… - Frontiers in plant …, 2022 - frontiersin.org
Plant-based heterologous expression systems can be leveraged to produce high-value
therapeutics, industrially important proteins, metabolites, and bioproducts. The production …

Production of the SARS-CoV-2 spike protein and its receptor binding domain in plant cell suspension cultures

BA Rebelo, A Folgado, AC Ferreira… - Frontiers in Plant …, 2022 - frontiersin.org
The COVID-19 pandemic, caused by the worldwide spread of SARS-CoV-2, has prompted
the scientific community to rapidly develop efficient and specific diagnostics and …

Transient Expression of Glycosylated SARS-CoV-2 Antigens in Nicotiana benthamiana

V Ruocco, R Strasser - Plants, 2022 - mdpi.com
The current COVID-19 pandemic very dramatically shows that the world lacks preparedness
for novel viral diseases. In addition to newly emerging viruses, many known pathogenic …

High-yield production of chimeric hepatitis E virus-like particles bearing the M2e influenza epitope and receptor binding domain of SARS-CoV-2 in plants using viral …

ES Mardanova, RY Kotlyarov… - International Journal of …, 2022 - mdpi.com
Capsid protein of Hepatitis E virus (HEV) is capable of self-assembly into virus-like particles
(VLPs) when expressed in Nicotiana benthamiana plants. Such VLPs could be used as …

[HTML][HTML] Immunogenicity of adjuvanted plant-produced SARS-CoV-2 Beta spike VLP vaccine in New Zealand white rabbits

MM O'Kennedy, C Abolnik, T Smith, T Motlou… - Vaccine, 2023 - Elsevier
The outbreak of the SARS-CoV-2 global pandemic heightened the pace of vaccine
development with various vaccines being approved for human use in a span of 24 months …

Performance of plant-produced RBDs as SARS-CoV-2 diagnostic reagents: a tale of two plant platforms

M Santoni, N Gutierrez-Valdes, D Pivotto… - Frontiers in Plant …, 2024 - frontiersin.org
The COVID-19 pandemic has underscored the need for rapid and cost-effective diagnostic
tools. Serological tests, particularly those measuring antibodies targeting the receptor …

Plant-derived recombinant vaccines against zoonotic viruses

G Zahmanova, K Takova, R Valkova, V Toneva… - Life, 2022 - mdpi.com
Emerging and re-emerging zoonotic diseases cause serious illness with billions of cases,
and millions of deaths. The most effective way to restrict the spread of zoonotic viruses …