Computer-aided design of 1, 4-naphthoquinone-based inhibitors targeting cruzain and rhodesain cysteine proteases
LR Silva, AS Guimaraes, J do Nascimento… - Bioorganic & Medicinal …, 2021 - Elsevier
Abstract Chagas disease and Human African Trypanosomiasis (HAT) are caused by
Trypanosoma cruzi and T. brucei parasites, respectively. Cruzain (CRZ) and Rhodesain …
Trypanosoma cruzi and T. brucei parasites, respectively. Cruzain (CRZ) and Rhodesain …
[HTML][HTML] Identification of (4-(9H-fluoren-9-yl) piperazin-1-yl) methanone derivatives as falcipain 2 inhibitors active against Plasmodium falciparum cultures
JE Hernández-González, E Salas-Sarduy… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Abstract Background Falcipain 2 (FP-2) is the hemoglobin-degrading cysteine protease of
Plasmodium falciparum most extensively targeted to develop novel antimalarials. However …
Plasmodium falciparum most extensively targeted to develop novel antimalarials. However …