The Western diet (WD) pattern characterized by high daily intake of saturated fats and
refined carbohydrates often leads to obesity and overweight, and it has been linked to …

In November 1955, Geoffrey Harris published a paper based on the Christian A Herter
Lecture he had given earlier that year at Johns Hopkins University in Baltimore, MD, USA …

Hypoxia is one of the most common and severe challenges to the maintenance of
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …

The metabolic prohormone pro-opiomelanocortin (POMC) is generally translocated into the
endoplasmic reticulum (ER) for entry into the secretory pathway. Patients with mutations …

Recent evidence suggests that Alzheimer's disease (AD) is closely linked with insulin
resistance, as seen in type 2 diabetes mellitus (T2DM). Insulin signaling is impaired in AD …

Neuropeptide Y (NPY), a neuropeptide highly conserved throughout evolution, is present at
high levels in the central nervous system (CNS), as well as in peripheral tissues such as the …

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women
of reproductive age. It is a heterogeneous condition characterized by reproductive …

Metabolic syndrome (MetS), which includes several clinical components such as abdominal
obesity, insulin resistance (IR), dyslipidemia, microalbuminuria, hypertension …

Objective Obesity, a growing threat to the modern society, represents an imbalance of
metabolic queues that normally signal to the arcuate hypothalamic nucleus, a critical brain …

The role of neuronal noncoding RNAs in energy control of the body is not fully understood.
The arcuate nucleus (ARC) of the hypothalamus comprises neurons regulating food intake …