[HTML][HTML] Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)

X Xu, KL Poulsen, L Wu, S Liu, T Miyata… - Signal transduction and …, 2022 - nature.com
Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

Age-related mitochondrial dysfunction as a key factor in COVID-19 disease

DJM Fernández-Ayala, P Navas… - Experimental gerontology, 2020 - Elsevier
SARS-CoV-2 causes a severe pneumonia (COVID-19) that affects essentially elderly
people. In COVID-19, macrophage infiltration into the lung causes a rapid and intense …

[HTML][HTML] Role of Coenzyme Q10 in Health and Disease: An Update on the Last 10 Years (2010–2020)

I Cirilli, E Damiani, PV Dludla, I Hargreaves… - Antioxidants, 2021 - mdpi.com
The present review focuses on preclinical and clinical studies conducted in the last decade
that contribute to increasing knowledge on Coenzyme Q10's role in health and disease …

[HTML][HTML] Detrimental effects of lipid peroxidation in type 2 diabetes: Exploring the neutralizing influence of antioxidants

SC Shabalala, R Johnson, AK Basson, K Ziqubu… - Antioxidants, 2022 - mdpi.com
Lipid peroxidation, including its prominent byproducts such as malondialdehyde (MDA) and
4-hydroxy-2-nonenal (4-HNE), has long been linked with worsened metabolic health in …

Adipokines as a therapeutic target by metformin to improve metabolic function: A systematic review of randomized controlled trials

PV Dludla, BB Nkambule, SE Mazibuko-Mbeje… - Pharmacological …, 2021 - Elsevier
Metformin is a widely used glucose-lowering drug, although its impact on adipose tissue
function remains elusive. Adipose tissue-derived molecules regulate diverse physiological …

Effect of coenzyme Q10 on cardiac function and survival in heart failure: an overview of systematic reviews and meta-analyses

E Alarcón-Vieco, I Martínez-García… - Food & Function, 2023 - pubs.rsc.org
Heart failure (HF) is associated with a deficiency in blood levels of coenzyme Q10 (CoQ10),
and its supplementation has been proposed. The aim of this systematic review was to …

Mitochondrial dysfunction in mouse livers depleted of iron chaperone PCBP1

S Jadhav, O Protchenko, F Li, E Baratz… - Free Radical Biology …, 2021 - Elsevier
Iron is an essential nutrient that forms cofactors required for the activity of hundreds of
cellular proteins. However, iron can be toxic and must be precisely managed. Poly r (C) …

[HTML][HTML] Effects of Coenzyme Q10 supplementation on biomarkers of oxidative stress in adults: a GRADE-Assessed systematic review and updated Meta-analysis of …

S Dai, Z Tian, D Zhao, Y Liang, M Liu, Z Liu, S Hou… - Antioxidants, 2022 - mdpi.com
Evidence shows that exogenous CoQ10 supplementation may potentially attenuate
oxidative stress status. However, its effective dose and evidence certainty require further …

[HTML][HTML] Alleviating effects of coenzyme Q10 supplements on biomarkers of inflammation and oxidative stress: results from an umbrella meta-analysis

S Dabbaghi Varnousfaderani, V Musazadeh… - Frontiers in …, 2023 - frontiersin.org
Introduction: Although several meta-analyses support the positive effect of coenzyme Q10
(CoQ10) on biomarkers of oxidative stress and inflammation, the results of some other …

Coenzyme Q10 in atherosclerosis

M Liao, X He, Y Zhou, W Peng, XM Zhao… - European Journal of …, 2024 - Elsevier
Atherosclerotic disease is a chronic disease that predominantly affects the elderly and is the
most common cause of cardiovascular death worldwide. Atherosclerosis is closely related to …