Proposed genetic approaches for reducing human malaria include population modification,
which introduces genes into vector mosquitoes to reduce or prevent parasite transmission …

Malaria is one of the deadliest diseases. Because of the ineffectiveness of current malaria-
control methods, several novel mosquito vector-based control strategies have been …

Only female insects transmit diseases such as malaria, dengue and Zika; therefore, control
methods that bias the sex ratio of insect offspring have long been sought. Genetic elements …

Gene drive systems that enable super-Mendelian inheritance of a transgene have the
potential to modify insect populations over a timeframe of a few years. We describe CRISPR …

Technologies for controlling mosquito vectors based on genetic manipulation and the
release of genetically modified mosquitoes (GMMs) are gaining ground. However, concrete …

Homing-based gene drives use a germline source of nuclease to copy themselves at
specific target sites in a genome and bias their inheritance. Such gene drives can be …

Genetic control aims to reduce the ability of insect pest populations to cause harm via the
release of modified insects. One strategy is to bias the reproductive sex ratio towards males …

To reproduce and to transmit disease, female mosquitoes must obtain blood meals and
locate appropriate sites for egg laying (oviposition). While distinct sensory cues drive each …

Plasmodium relies on numerous agonists during its journey through the mosquito vector,
and these agonists represent potent targets for transmission-blocking by either inhibiting or …

Wolbachia, a maternally inherited intracellular bacterial species, can manipulate host insect
reproduction by cytoplasmic incompatibility (CI), which results in embryo lethality in crosses …