Molecular mechanisms of antibiotic resistance revisited
EM Darby, E Trampari, P Siasat, MS Gaya… - Nature Reviews …, 2023 - nature.com
Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics
currently in clinical use and only a few novel drugs in the pipeline. Understanding the …
currently in clinical use and only a few novel drugs in the pipeline. Understanding the …
Tolerance and resistance of microbial biofilms
Chronic infections caused by microbial biofilms represent an important clinical challenge.
The recalcitrance of microbial biofilms to antimicrobials and to the immune system is a major …
The recalcitrance of microbial biofilms to antimicrobials and to the immune system is a major …
Biology and evolution of bacterial toxin–antitoxin systems
Toxin–antitoxin systems are widespread in bacterial genomes. They are usually composed
of two elements: a toxin that inhibits an essential cellular process and an antitoxin that …
of two elements: a toxin that inhibits an essential cellular process and an antitoxin that …
Biomaterial-based antimicrobial therapies for the treatment of bacterial infections
PP Kalelkar, M Riddick, AJ García - Nature Reviews Materials, 2022 - nature.com
The rise in antibiotic-resistant bacteria, including strains that are resistant to last-resort
antibiotics, and the limited ability of antibiotics to eradicate biofilms have necessitated the …
antibiotics, and the limited ability of antibiotics to eradicate biofilms have necessitated the …
Antidepressants can induce mutation and enhance persistence toward multiple antibiotics
Antibiotic resistance is an urgent threat to global health. Antidepressants are consumed in
large quantities, with a similar pharmaceutical market share (4.8%) to antibiotics (5%). While …
large quantities, with a similar pharmaceutical market share (4.8%) to antibiotics (5%). While …
Antibiotic resistance and persistence—Implications for human health and treatment perspectives
Antimicrobial resistance (AMR) and persistence are associated with an elevated risk of
treatment failure and relapsing infections. They are thus important drivers of increased …
treatment failure and relapsing infections. They are thus important drivers of increased …
The stringent response and physiological roles of (pp) pGpp in bacteria
SE Irving, NR Choudhury, RM Corrigan - Nature Reviews Microbiology, 2021 - nature.com
The stringent response is a stress signalling system mediated by the alarmones guanosine
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …
Clinically relevant mutations in core metabolic genes confer antibiotic resistance
Although metabolism plays an active role in antibiotic lethality, antibiotic resistance is
generally associated with drug target modification, enzymatic inactivation, and/or transport …
generally associated with drug target modification, enzymatic inactivation, and/or transport …
[HTML][HTML] The science of antibiotic discovery
K Lewis - Cell, 2020 - cell.com
We are experiencing an antimicrobial resistance (AMR) crisis, brought on by the drying up of
the antibiotic discovery pipeline and the resulting unchecked spread of resistant pathogens …
the antibiotic discovery pipeline and the resulting unchecked spread of resistant pathogens …
Antimicrobial resistance in bacteria: mechanisms, evolution, and persistence
E Christaki, M Marcou, A Tofarides - Journal of molecular evolution, 2020 - Springer
In recent years, we have seen antimicrobial resistance rapidly emerge at a global scale and
spread from one country to the other faster than previously thought. Superbugs and …
spread from one country to the other faster than previously thought. Superbugs and …