Gender differences in depression: biological, affective, cognitive, and sociocultural factors
JS Hyde, AH Mezulis - Harvard review of psychiatry, 2020 - journals.lww.com
The odds ratio (OR) for gender differences in major depression is 1.95, averaged meta-
analytically over all ages and nations. The gender difference appears by age 12, OR= 2.37 …
analytically over all ages and nations. The gender difference appears by age 12, OR= 2.37 …
Understanding the pathophysiology of depression: From monoamines to the neurogenesis hypothesis model-are we there yet?
E Jesulola, P Micalos, IJ Baguley - Behavioural brain research, 2018 - Elsevier
A number of factors (biogenic amine deficiency, genetic, environmental, immunologic,
endocrine factors and neurogenesis) have been identified as mechanisms which provide …
endocrine factors and neurogenesis) have been identified as mechanisms which provide …
The genetic architecture of depression in individuals of East Asian ancestry: a genome-wide association study
Importance Most previous genome-wide association studies (GWAS) of depression have
used data from individuals of European descent. This limits the understanding of the …
used data from individuals of European descent. This limits the understanding of the …
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference
X Meng, G Navoly, O Giannakopoulou, DF Levey… - Nature …, 2024 - nature.com
Most genome-wide association studies (GWAS) of major depression (MD) have been
conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD …
conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD …
The genetic basis of major depression
Major depressive disorder (MDD) is a common, debilitating, phenotypically heterogeneous
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …
Etiology in psychiatry: embracing the reality of poly‐gene‐environmental causation of mental illness
Intriguing findings on genetic and environmental causation suggest a need to reframe the
etiology of mental disorders. Molecular genetics shows that thousands of common and rare …
etiology of mental disorders. Molecular genetics shows that thousands of common and rare …
Gene-environment interaction and psychiatric disorders: Review and future directions
Empirical studies suggest that psychiatric disorders result from a complex interplay between
genetic and environmental factors. Most evidence for such gene-environment interaction …
genetic and environmental factors. Most evidence for such gene-environment interaction …
A genome-wide association study of suicide attempts in the million veterans program identifies evidence of pan-ancestry and ancestry-specific risk loci
NA Kimbrel, AE Ashley-Koch, XJ Qin, JH Lindquist… - Molecular …, 2022 - nature.com
To identify pan-ancestry and ancestry-specific loci associated with attempting suicide among
veterans, we conducted a genome-wide association study (GWAS) of suicide attempts within …
veterans, we conducted a genome-wide association study (GWAS) of suicide attempts within …
Sex-specific role for the long non-coding RNA LINC00473 in depression
Depression is a common disorder that affects women at twice the rate of men. Here, we
report that long non-coding RNAs (lncRNAs), a recently discovered class of regulatory …
report that long non-coding RNAs (lncRNAs), a recently discovered class of regulatory …
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank
Depression is more frequent among individuals exposed to traumatic events. Both trauma
exposure and depression are heritable. However, the relationship between these traits …
exposure and depression are heritable. However, the relationship between these traits …