Histones have a long history of research in a wide range of species, leaving a legacy of
complex nomenclature in the literature. Community-led discussions at the EMBO Workshop …

Most methods for single-cell transcriptome sequencing amplify the termini of polyadenylated
transcripts, capturing only a small fraction of the total cellular transcriptome. This precludes …

Background The oncogenic role of histone mutations is one of the most relevant discovery in
cancer epigenetics. Recurrent mutations targeting histone genes have been described in …

In cardiovascular tissues, changes in the mechanical properties of the extracellular matrix
are associated with cellular de-differentiation and with subsequent functional declines …

Male gametes are generated through a specialised differentiation pathway involving a
series of developmental transitions that are poorly characterised at the molecular level …

The spermatozoon is a highly differentiated cell with unique characteristics: it is mobile,
thanks to its flagellum, and is very compact. The sperm cytoplasm is extremely reduced …

Little is known about the roles of histone tails in modulating nucleosomal DNA accessibility
and its recognition by other macromolecules. Here we generate extensive atomic level …

Histone variants are chromatin components that replace replication-coupled histones in a
fraction of nucleosomes and confer particular characteristics to chromatin. H2A variants …

All proteins end with a carboxyl terminus that has unique biophysical properties and is often
disordered. Although there are examples of important C-termini functions, a more global role …

Eukaryotic genomes must accomplish both compact packaging for genome stability and
inheritance, as well as accessibility for gene expression. They do so using post-translational …