We review progress towards greater mechanistic understanding and clinical translation of a
strategy to improve respiratory and non-respiratory motor function in people with …

While spinal cord injuries (SCIs) result in a vast array of functional deficits, many of which
are life threatening, the majority of SCIs are anatomically incomplete. Spared neural …

High spinal cord injuries (SCIs) lead to permanent functional deficits, including respiratory
dysfunction. Patients living with such conditions often rely on ventilatory assistance to …

Cervical spinal cord injury (cSCI) severs bulbospinal projections to respiratory motor
neurons, paralyzing respiratory muscles below the injury. C2 spinal hemisection (C2Hx) is a …

The study of respiratory plasticity in animal models spans decades. At the bench,
researchers use an array of techniques aimed at harnessing the power of plasticity within …

Complete spinal cord injury (SCI) leads to permanent motor, sensitive and sensory deficits.
In humans, there is currently no therapy to promote recovery and the only available …

Brief exposure to systemic hypoxia enhances plasticity of th... : Current Opinion in Neurology
Brief exposure to systemic hypoxia enhances plasticity of the central nervous system in spinal …

Impaired respiratory function is a common and devastating consequence of cervical spinal
cord injury. Accordingly, the development of safe and effective treatments to restore …

Plasticity is a hallmark of the respiratory neural control system. Phrenic long-term facilitation
(pLTF) is one form of respiratory plasticity characterized by persistent increases in phrenic …

Abstract Low-dose (< 2 h/day), acute intermittent hypoxia (AIH) elicits multiple forms of
serotonin-dependent phrenic motor plasticity and is emerging as a promising therapeutic …